Development and construction of a neutron beam line for accelerator-based boron neutron capture synovectomy.
Development and construction of a neutron beam line for accelerator-based boron neutron capture synovectomy.
复制标题
开发和建造用于基于加速器的硼中子俘获滑膜切除术的中子束线。
DOI：
10.1118/1.598885
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发表时间：
2000
期刊：
影响因子：
3.8
通讯作者：
Shefer,RE
中科院分区：
文献类型：
--
作者：
Gierga,DP;Yanch,JC;Shefer,RE
核反应用于治疗类风湿性关节炎的潜在应用，称为硼中子捕获滑膜切除术（BNCS），正在研究中。在关节炎关节中，滑液衬里会发炎，这是患者巨大疼痛和不适的根源。BNCS的目标是消融滑膜，从而消除关节炎的症状。BNCS治疗包括关节内注射硼，然后对关节进行中子照射。蒙特卡罗辐射输运计算已用于开发用于BNCS治疗的基于加速器的超热中子束线。该模型包括一个减速器/反射器组件，中子产生的目标，目标冷却系统，关节炎关节幻影。已对人膝关节、人手指和兔膝关节进行了单光束和平行反向光束辐照建模。额外的反射器，放置在关节的侧面和背面，已被添加到模型中，并已被证明可以将治疗时间和皮肤剂量提高约2倍。BNCS的几个产生中子的带电粒子反应已经被研究过，包括质子能量为4和3.7 MeV的反应，氘能量为1.5和2.6 MeV的反应，以及质子能量为2.5 MeV的反应。对于1 mA的加速器射束电流和1000 ppm的滑膜硼摄取，递送10 000 RBE cGy的治疗剂量的时间范围为3至48 min，取决于治疗的关节和中子产生带电粒子反应。 尽管屏蔽配置尚未优化，但对于1000 ppm或19 000 ppm的滑膜硼摄取量，膝关节治疗期间人体将承受的全身有效剂量估计分别为3.6 rem或0.75 rem。蒙特卡罗设计过程最终在马萨诸塞州理工学院加速器束流应用实验室的强流串列静电加速器上建造、安装和测试了专用BNCS束流线。
A potential application of the nuclear reaction for the treatment of rheumatoid arthritis, termed Boron Neutron Capture Synovectomy (BNCS), is under investigation. In an arthritic joint, the synovial lining becomes inflamed and is a source of great pain and discomfort for the afflicted patient. The goal of BNCS is to ablate the synovium, thereby eliminating the symptoms of the arthritis. A BNCS treatment would consist of an intra‐articular injection of boron followed by neutron irradiation of the joint. Monte Carlo radiation transport calculations have been used to develop an accelerator‐based epithermal neutron beam line for BNCS treatments. The model includes a moderator/reflector assembly, neutron producing target, target cooling system, and arthritic joint phantom. Single and parallel opposed beam irradiations have been modeled for the human knee, human finger, and rabbit knee joints. Additional reflectors, placed to the side and back of the joint, have been added to the model and have been shown to improve treatment times and skin doses by about a factor of 2. Several neutron‐producing charged particle reactions have been examined for BNCS, including the reaction at proton energies of 4 and 3.7 MeV, the reaction at deuteron energies of 1.5 and 2.6 MeV, and the reaction at a proton energy of 2.5 MeV. For an accelerator beam current of 1 mA and synovial boron uptake of 1000 ppm, the time to deliver a therapy dose of 10 000 RBE cGy ranges from 3 to 48 min, depending on the treated joint and the neutron producing charged particle reaction. The whole‐body effective dose that a human would incur during a knee treatment has been estimated to be 3.6 rem or 0.75 rem, for 1000 ppm or 19 000 ppm synovial boron uptake, respectively, although the shielding configuration has not yet been optimized. The Monte Carlo design process culminated in the construction, installation, and testing of a dedicated BNCS beam line on the high‐current tandem electrostatic accelerator at the Laboratory for Accelerator Beam Applications at the Massachusetts Institute of Technology.