Zoning in on podocytes.
Zoning in on podocytes.
复制标题
足细胞分区。
DOI：
10.1016/j.kint.2022.08.030
复制
发表时间：
2022
影响因子：
19.6
通讯作者：
Wessely,Oliver
中科院分区：
文献类型：
--
作者：
Shankland,StuartJ;Wessely,Oliver
足细胞在发育、稳态、衰老和损伤过程中发生明确的形态学变化。足细胞禀赋的定量足量计评估提供了一个强有力的工具，询问肾小球健康。将这种方法扩展到区域评估表明，来自皮质、皮质下和肾上腺髓质肾小球的足细胞不仅本身在形态上是异质的，而且对压力源（如年龄和高血压）的反应也不同。这表明，带状肾小球的变化蕴藏着重要的信息，以了解肾小球疾病。
Podocytes undergo defined morphologic changes during development, homeostasis, and aging, and on injury. Quantitative podometric assessments of podocyte endowment provide a powerful tool to interrogate glomerular health. Expanding this approach to a regional assessment demonstrates that the podocytes from cortical, subcortical, and juxtamedullary glomeruli are not only morphologically heterogeneous per se, but respond differently to stressors, such as age and hypertension. This suggests that zonal glomerular changes harbor critical information to understand glomerulopathies.