Myelin from MAG-deficient mice is a strong inhibitor of neurite outgrowth
Myelin from MAG-deficient mice is a strong inhibitor of neurite outgrowth
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DOI：
10.1097/00001756-199603220-00005
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发表时间：
1996-03-22
期刊：
影响因子：
1.7
通讯作者：
Lozano, A
中科院分区：
文献类型：
--
作者：
Ng, WP;Cartel, N;Lozano, A
髓磷脂相关糖蛋白（MAG）在体外具有有效的神经突起生长抑制活性。为了评估MAG在CNS髓磷脂中的神经突生长抑制活性中的重要性，我们使用体外生物测定来表征来自携带MAG基因无效突变的小鼠的CNS髓磷脂上的神经突生长。来自MAG缺陷小鼠的髓鞘蛋白抑制神经突生长的程度与野生型CNS髓鞘相似。这些结果表明，中枢神经系统髓鞘分子以外的MAG神经突起的生长产生强烈的抑制作用。
MYELIN-associated glycoprotein (MAG) has potent neurite outgrowth inhibitory activity in vitro. To assess the importance of MAG in the neurite outgrowth inhibitory activity in CNS myelin, we used an in vitro bioassay to characterize neurite growth on CNS myelin derived from mice carrying a null mutation of the MAG gene. Myelin proteins from MAG-deficient mice inhibited neurite outgrowth to a similar degree to the wild-type CNS myelin. These results suggest that CNS myelin molecules other than MAG exert strong inhibitory effects on the growth of neurites.