Serum cystatin C and anti-N-methyl-D-aspartate receptor encephalitis
Serum cystatin C and anti-N-methyl-D-aspartate receptor encephalitis
复制标题
血清胱抑素C和抗-N-甲基-D-天冬氨酸受体脑炎
DOI：
10.1111/ane.12894
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发表时间：
2018-05-01
影响因子：
3.5
通讯作者：
Qiu, W.
中科院分区：
文献类型：
--
作者：
Shu, Y.;Chang, Y.;Qiu, W.
CysC与多种神经退行性疾病和自身免疫性疾病有关，但与抗N-甲基-D-天冬氨酸受体（anti-NMDAR）脑炎的关系尚不清楚。在66例患者中，30例在入院后3个月进行了随访评估。结果抗NMDAR脑炎患者血清CysC水平显著低于对照组（0.70 ± 0.13vs0.83 ± 0.17mg/mL，P < 0.01）。
BackgroundCystatin C (CysC) is associated with many neurodegenerative disorders and autoimmune diseases, but its relationship with anti-N-Methyl-D-aspartate receptor (anti-NMDAR) encephalitis is unknown.MethodsSerum levels of CysC were determined in 66 patients with anti-NMDAR encephalitis and 115 healthy controls. Of the 66 patients, 30 had a follow-up evaluation at 3months after admission. Association of CysC with anti-NMDAR encephalitis and its clinical parameters were evaluated in the patients.ResultsThe serum levels of CysC were significantly lower in patients with anti-NMDAR encephalitis than in controls (0.700.13 vs 0.83 +/- 0.17mg/mL, P