Cardiac aging and heart disease in humans.
Cardiac aging and heart disease in humans.
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DOI：
10.1007/s12551-017-0255-9
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发表时间：
2017-04-01
影响因子：
--
通讯作者：
Lande, Gilles
中科院分区：
文献类型：
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作者：
Steenman, Marja;Lande, Gilles
世界人口继续迅速老龄化，主要原因是生育率下降和寿命延长。由于年龄是心血管疾病的最大危险因素，这些疾病的患病率随着年龄的增长而急剧增加。为了改善患者的护理和预防与年龄相关的心脏疾病，洞察力应该从参与和导致心脏衰老的过程的分析中获得。正是从这个角度，我们在这里提供了一个概述与年龄相关的心脏在四个层面上的变化：功能，结构，细胞和分子。我们强调这些变化是在两个主要的年龄相关的心脏病的发展共同的：心力衰竭和心房颤动。这些在衰老和心脏病理生理学中普遍受影响的过程可能为心脏病的年龄风险因素提供了解释。
The world population continues to grow older rapidly, mostly because of declining fertility and increasing longevity. Since age represents the largest risk factor for cardiovascular disease, the prevalence of these pathologies increases dramatically with increasing age. In order to improve patient care and prevention for age-related cardiac diseases, insight should be gained from the analysis of processes involved in and leading to cardiac aging. It is from this perspective that we provide here an overview of changes associated with age in the heart on four levels: functional, structural, cellular and molecular. We highlight those changes that are in common with the development of the two major age-associated cardiac pathologies: heart failure and atrial fibrillation. These commonly affected processes in aging and cardiac pathophysiology may provide an explanation for the age risk factor in cardiac disease.