Direction-specific disruption of subcortical visual behavior and receptive fields in mice lacking the beta2 subunit of nicotinic acetylcholine receptor.
Direction-specific disruption of subcortical visual behavior and receptive fields in mice lacking the beta2 subunit of nicotinic acetylcholine receptor.
复制标题
DOI：
10.1523/jneurosci.2128-09.2009
复制
发表时间：
2009-10-14
期刊：
影响因子：
--
通讯作者：
Cang J
中科院分区：
文献类型：
--
作者：
Wang L;Rangarajan KV;Lawhn-Heath CA;Sarnaik R;Wang BS;Liu X;Cang J
视网膜定位是视觉系统组织的基本特征，但其在视觉信息处理中的作用尚不清楚。缺乏烟碱乙酰胆碱受体β2亚基的突变小鼠在视觉皮层（V1）和上丘（SC）中都有不精确的定位，这是由于在发育过程中自发视网膜活动受到破坏。本文采用行为学和生理学的方法来研究它们的视觉功能。我们发现β2 - / -小鼠在皮层下视运动行为中不能跟踪沿鼻颞轴移动的视觉刺激，但可以正常地沿着背腹轴跟踪。相比之下，这些小鼠在视觉水任务（一种皮质功能的行为测试）中，在两个轴上都表现出正常的敏锐度。与行为结果一致，我们发现β2−/−小鼠的V1神经元具有正常的反应特性，而SC神经元破坏了感受野，包括结构扩大和沿鼻颞轴方向和定向选择性降低。皮层下特异性缺陷表明，视网膜定位图破坏对V1和SC功能特性的发展有不同的影响。
Retinotopic mapping is a basic feature of visual system organization, but its role in processing visual information is unknown. Mutant mice lacking β2 subunit of nicotinic acetylcholine receptor have imprecise maps in both visual cortex (V1) and the superior colliculus (SC) due to the disruption of spontaneous retinal activity during development. Here, we use behavioral and physiological approaches to study their visual functions. We find that β2−/− mice fail to track visual stimuli moving along the nasotemporal axis in a subcortical optomotor behavior, but track normally along the dorsoventral axis. In contrast, these mice display normal acuity along both axes in the visual water task, a behavioral test of cortical functions. Consistent with the behavioral results, we find that V1 neurons in β2−/− mice have normal response properties, while SC neurons have disrupted receptive fields, including enlarged structure and decreased direction and orientation selectivity along the nasotemporal axis. The subcortical-specific deficits indicate that retinotopic map disruption has different impacts on the development of functional properties in V1 and the SC.