Childhood adversity and hippocampal and amygdala volumes in a population at familial high risk of schizophrenia
Childhood adversity and hippocampal and amygdala volumes in a population at familial high risk of schizophrenia
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DOI：
10.1016/j.schres.2016.04.028
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发表时间：
2016-08-01
影响因子：
4.5
通讯作者：
Lawrie, S. M.
中科院分区：
文献类型：
--
作者：
Barker, V.;Bois, C.;Lawrie, S. M.
背景：儿童时期的逆境(CA)与精神分裂症之间存在着既定的联系。在精神分裂症的高家族风险(FHR)患者中，海马体和杏仁核的异常发生在发病前，但在精神分裂症的高危人群中，这些变化是否与CA有关尚不清楚。方法：我们检测了FHR中被转介给社会工作者或儿童小组的患者与未被转介的患者的海马体和杏仁核体积。结果：在那些被转介到社会工作和儿童小组的患者中，右侧海马和左侧杏仁核显著缩小。结论：我们的研究结果表明，CA可以影响精神分裂症FHR队列中大脑结构的变化。这些发现进一步证明，虽然遗传因素导致了精神分裂症的结构变化，但CA等环境因素可以对特定的大脑区域产生持久的影响。(C)2016爱思唯尔B.V.保留所有权利。
Background: There is an established link between childhood adversity (CA) and schizophrenia. Hippocampus and amygdala abnormalities pre-date onset in those at high familial risk (fHR) of schizophrenia, but it is not clear whether these alterations are associated with CA in those at elevated risk of schizophrenia.Methods: We examined hippocampal and amygdala volumes in those at fHR who had been referred to a social worker or the Children's Panel compared to those who had not.Results: The right hippocampus and left amygdala were significantly smaller in those that had been referred to social work and Children's Panel.Conclusions: Our findings suggest that CA can influence structural changes in the brain in a cohort at fHR of schizophrenia. These findings provide further evidence that while genetic factors contribute to the structural changes found in schizophrenia, environmental factors such as CA can have a lasting impact on specific brain regions. (C) 2016 Elsevier B.V. All rights reserved.