Mover is a novel vertebrate-specific presynaptic protein with differential distribution at subsets of CNS synapses
Mover is a novel vertebrate-specific presynaptic protein with differential distribution at subsets of CNS synapses
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DOI：
10.1016/j.febslet.2007.08.070
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发表时间：
2007-10-02
期刊：
影响因子：
3.5
通讯作者：
Dresbach, Thomas
中科院分区：
文献类型：
--
作者：
Kremer, Thomas;Kempf, Christian;Dresbach, Thomas
突触前神经末梢含有支架蛋白，在活跃区协调神经递质释放。在这里，我们描述了一种未知的非跨膜蛋白mover，当在培养的神经元中过表达时，它的目标是突触前终末。共聚焦免疫显微镜显示移植物与胼胝体花萼中的突触前标记共定位。在海马体中，移动器定位于苔藓纤维末端，但不在抑制性神经末端。相比之下，移动器定位于整个小脑皮层的抑制性终末。我们的研究结果表明，在不同的突触前终末中，移动蛋白可能与普遍表达的支架蛋白协同作用。(c) 2007年欧洲生化学会联合会。Elsevier B.V.版权所有。
Presynaptic nerve terminals contain scaffolding proteins that orchestrate neurotransmitter release at active zones. Here we describe mover, a yet unknown non-transmembrane protein that is targeted to presynaptic terminals when overexpressed in cultured neurons. Confocal immunomicroscopy revealed that mover colocalizes with presynaptic markers in the calyx of Held. In the hippocampus, mover localizes to mossy fibre terminals, but is absent from inhibitory nerve terminals. By contrast, mover localizes to inhibitory terminals throughout the cerebellar cortex. Our results suggest that mover may act in concert with generally expressed scaffolding proteins in distinct sets of presynaptic terminals. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.