Glucose tolerance in young and older athletes and sedentary men.
Glucose tolerance in young and older athletes and sedentary men.
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年轻和老年运动员以及久坐男性的葡萄糖耐量。
DOI：
10.1152/jappl.1984.56.6.1521
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Holloszy,JO
中科院分区：
文献类型：
--
作者：
Seals,DR;Hagberg,JM;Allen,WK;Hurley,BF;Dalsky,GP;Ehsani,AA;Holloszy,JO
对受过耐力训练的主要运动员(60+/-2岁)、未受训练的老年男性(62+/-1岁)、瘦的未受训练的老年男性(61+/-2岁)、受过耐力训练的年轻运动员(26+/-1岁)和年轻的未受训练的男性(28+/-1年)进行了研究，以获得年龄、体力活动和体脂对糖耐量和胰岛素敏感性的单独影响的信息。每个受试者都接受了100克的口服葡萄糖耐量测试。测量6个部位的皮褶厚度。与久坐不动的同龄人相比，训练组的最大吸氧量更高，皮褶总和更低。苗条的老年未训练组的皮褶总数与年轻的未训练组相似。高手运动员、年轻运动员和未经训练的年轻男子表现出相似的糖耐量，而两个年龄较大的未经训练的组的葡萄糖曲线下总面积几乎增加了两倍(P<0.05)。与其他三组相比，大师和青年运动员的血浆胰岛素反应明显减弱(P<0.05)。年轻和瘦削的老年未训练组的胰岛素反应相似，胰岛素水平显著低于老年未训练组(P<0.05)。这些结果提供的证据表明，在一些人中，经常进行剧烈运动可以防止葡萄糖耐量和胰岛素敏感性随着年龄的增长而恶化。
Groups of endurance-trained masters athletes (60 +/- 2 yr), older untrained men (62 +/- 1 yr), lean older untrained men (61 +/- 2 yr), endurance-trained young athletes (26 +/- 1 yr), and young untrained men (28 +/- 1 yr) were studied to obtain information on the separate effects of age, physical activity, and body fatness on glucose tolerance and insulin sensitivity. Each subject underwent an oral 100-g glucose tolerance test. Skinfold thickness was determined at six sites. The trained groups had a higher maximum O2 uptake capacity and lower sum of skinfolds than their sedentary peers. The lean older untrained group had a sum of skinfolds similar to that of the young untrained group. The masters athletes, young athletes, and young untrained men exhibited similar glucose tolerance whereas the two older untrained groups had an almost twofold greater total area under the glucose curve (P less than 0.05). The masters and young athletes had significantly blunted plasma insulin responses compared with the other three groups (P less than 0.05). The young and the lean older untrained groups had similar plasma insulin responses with significantly lower insulin levels than the older untrained group (P less than 0.05). These results provide evidence that regularly performed vigorous exercise can, in some individuals, prevent the deterioration of glucose tolerance and insulin sensitivity with age.