Short-Term Antiretroviral Treatment Recommendations Based on Sensitivity Analysis of a Mathematical Model for HIV Infection of CD4+T Cells
Short-Term Antiretroviral Treatment Recommendations Based on Sensitivity Analysis of a Mathematical Model for HIV Infection of CD4+T Cells
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DOI：
10.1007/s11538-017-0345-7
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发表时间：
2017-11-01
影响因子：
3.5
通讯作者：
Hussaini, M. Yousuff
中科院分区：
文献类型：
--
作者：
Croicu, Ana-Maria;Jarrett, Angela M.;Hussaini, M. Yousuff
艾滋病毒感染是最难控制和管理的感染之一。根据使用的指南(美国、欧洲、世卫组织)，控制这种感染的最新建议各不相同，而且不是针对患者的。不幸的是，没有两个人对感染和治疗的反应完全相同。这篇文章的目的是利用不确定性和敏感性分析来调查针对患者的可能的短期治疗方案。我们能够确定对艺术结果负责的最重要的参数，并对艺术的成功提出一些见解。
HIV infection is one of the most difficult infections to control and manage. The most recent recommendations to control this infection vary according to the guidelines used (US, European, WHO) and are not patient-specific. Unfortunately, no two individuals respond to infection and treatment quite the same way. The purpose of this paper is to make use of the uncertainty and sensitivity analysis to investigate possible short-term treatment options that are patient-specific. We are able to identify the most significant parameters that are responsible for ART outcome and to formulate some insights into the ART success.