Exploring neoglycoprotein assembly through native chemical ligation using neoglycopeptide thioesters prepared via N→S acyl transfer
Exploring neoglycoprotein assembly through native chemical ligation using neoglycopeptide thioesters prepared via N→S acyl transfer
复制标题
DOI：
10.1039/b920535g
复制
发表时间：
2010-03-21
影响因子：
3.2
通讯作者：
Macmillan, Derek
中科院分区：
文献类型：
--
作者：
Richardson, Jonathan P.;Chan, Chung-Hei;Macmillan, Derek
糖和简化的寡糖“模拟物”可以通过可靠的化学反应在预先定义的位点与蛋白质片段连接，例如硫醇烷基化和Cu(I)催化叠氮化物/乙炔连接（点击化学）。这些片段有可能通过天然化学结扎组装成新的糖蛋白治疗剂。
Sugars and simplified oligosaccharide "mimics" can be joined with protein fragments at pre-defined sites using reliable chemical reactions such as thiol alkylation and Cu(I) catalysed azide/acetylene ligation (click chemistry). These fragments have the potential to be assembled into neoglycoprotein therapeutics using native chemical ligation.