Endocrinological and pathological effects of anabolic-androgenic steroid in male rats.
Endocrinological and pathological effects of anabolic-androgenic steroid in male rats.
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DOI：
10.1507/endocrj.51.425
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发表时间：
2004-08
影响因子：
2
通讯作者：
Masato Takahashi;Y. Tatsugi;T. Kohno
中科院分区：
文献类型：
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作者：
Masato Takahashi;Y. Tatsugi;T. Kohno
许多运动员使用药物，特别是合成代谢雄激素类固醇（AAS），但有关AAS滥用者内分泌和病理变化的报道很少。在这项研究中，我们报告了接受 AAS 的大鼠的内分泌检查结果以及身体变化。我们将 37 只雄性 Wistar 大鼠（7 周龄）分为 3 组：A 组服用癸酸诺龙、醋酸美替诺龙和屈他雄龙； B组用癸酸诺龙和生理盐水； C组只给予生理盐水。他们每周皮下注射一次药物或对照载体，持续 6 周。停药 4 周，然后又恢复 6 周。之后，处死大鼠。 A组血清睾酮水平显着高于C组。A组血清二氢睾酮水平显着高于B、C组。A、B组血清雌二醇-17β水平显着高于C组。病理评估心脏、睾丸、肾上腺严重受损。这些发现表明，使用 AAS 存在高度风险。
Many athletes use drugs, especially anabolic androgenic steroids (AAS), but there are few reports on the endocrinological and pathological changes in AAS abusers. In this study we reported the results of endocrinological examinations in rats administered AAS and also physical changes. We separated 37 male Wistar rats (7 weeks old) into 3 groups: Group A was medicated with nandrolone decanoate, metenolone acetate, and dromostanolone; Group B with nandrolone decanoate and saline; and Group C was given only saline. They were given subcutaneous injections of the medications or the control vehicle once a week for 6 weeks. Medications were stopped for 4 weeks, and then resumed for another 6 weeks. After that, rats were sacrificed. Serum testosterone level in Group A was significantly higher than that in Group C. Serum dihydrotestosterone in Group A was significantly higher than that in both Groups B and C. Serum estradiol-17beta levels in Groups A and B were significantly higher than that in Group C. In pathological evaluation, heart, testis, and adrenal gland were severely damaged. These findings indicate that there is a high degree of risk related to the use of AAS.