Vitamin D levels and disease status in Texas patients with systemic lupus erythematosus
Vitamin D levels and disease status in Texas patients with systemic lupus erythematosus
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DOI：
10.1097/maj.0b013e318134eeb6
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发表时间：
2008-02-01
影响因子：
3.1
通讯作者：
Olsen, Nancy J.
中科院分区：
文献类型：
--
作者：
Thudi, Amitha;Yin, Su;Olsen, Nancy J.
目的：先前的研究表明低水平的血清维生素D与狼疮有关。维生素D受体配体可以介导免疫抑制效应，低水平的这种激素被认为有助于狼疮和其他自身免疫性疾病的免疫激活。我们试图调查狼疮患者中维生素D缺乏的患病率。方法：采用双抗体夹心酶联免疫法测定37例女性狼疮患者血清25-羟基维生素D水平。确定了与临床和免疫学指标的相关性。结果和结论：大约65%的狼疮患者的维生素D水平低于80nmol，这是维生素D充分性的下限。此外，20%的受试者的25-羟基维生素D水平低于检测的正常范围(
Objectives: Previous studies have suggested a relationship between low serum levels of vitamin D and lupus. Vitamin D receptor ligands can mediate immunosuppressive effects and low levels of this hormone have been proposed as contributing to the immune activation in lupus and other autoimmune diseases. We sought to investigate the prevalence of vitamin D insufficiency in our patients with lupus. Methods: Serum levels of 25-OH vitamin D were measured in 37 female patients with lupus using an enzyme-linked immunoassay. Correlations with clinical and immunologic measures were determined. Results and Conclusions: Approximately 65% of the patients with lupus had values less than 80 nmol, which is accepted as the lower limit of vitamin D adequacy. In addition, 20% of the subjects had levels of 25-hydroxyvitamin D that were lower than the normal range for the assay (