Shared mechanisms of auditory and non-auditory vocal learning in the songbird brain.
Shared mechanisms of auditory and non-auditory vocal learning in the songbird brain.
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DOI：
10.7554/elife.75691
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发表时间：
2022-09-15
期刊：
影响因子：
7.7
通讯作者：
Sober SJ
中科院分区：
文献类型：
--
作者：
McGregor JN;Grassler AL;Jaffe PI;Jacob AL;Brainard MS;Sober SJ
鸣禽和人类都有根据感觉反馈自适应地修改发声的能力。先前的研究主要集中在听觉反馈在塑造整个生命中的声音输出中所起的作用。相比之下，目前还不清楚非听觉信息如何驱动声音可塑性。在这里，我们首先使用强化学习范式来建立体感反馈（皮肤电刺激）可以驱动成年鸣禽的发声学习。然后，我们评估了鸣禽基底神经节丘脑皮质通路的作用，听觉声乐学习在这种新形式的声乐可塑性的关键。我们发现，这一电路及其多巴胺能输入是必要的非听觉声乐学习，这表明这一途径是至关重要的指导适应性声乐变化的基础上，听觉和体感信号。这个回路使用听觉和体感信息来指导发声学习的能力可能反映了支持跨物种发声可塑性的神经系统的一般原理。
Songbirds and humans share the ability to adaptively modify their vocalizations based on sensory feedback. Prior studies have focused primarily on the role that auditory feedback plays in shaping vocal output throughout life. In contrast, it is unclear how non-auditory information drives vocal plasticity. Here, we first used a reinforcement learning paradigm to establish that somatosensory feedback (cutaneous electrical stimulation) can drive vocal learning in adult songbirds. We then assessed the role of a songbird basal ganglia thalamocortical pathway critical to auditory vocal learning in this novel form of vocal plasticity. We found that both this circuit and its dopaminergic inputs are necessary for non-auditory vocal learning, demonstrating that this pathway is critical for guiding adaptive vocal changes based on both auditory and somatosensory signals. The ability of this circuit to use both auditory and somatosensory information to guide vocal learning may reflect a general principle for the neural systems that support vocal plasticity across species.
影响因子：
3.3
作者：
Kuebrich, B. D.;Sober, S. J.
通讯作者：
Sober, S. J.