Plasma thioredoxin levels in patients with unstable angina
Plasma thioredoxin levels in patients with unstable angina
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DOI：
10.1016/j.ijcard.2004.01.010
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发表时间：
2005-03-18
影响因子：
3.5
通讯作者：
Ogawa, H
中科院分区：
文献类型：
--
作者：
Hokamaki, J;Kawano, H;Ogawa, H
人硫氧还蛋白的血浆水平表明对氧化应激的反应。我们测量了不稳定型心绞痛患者的血浆硫氧还蛋白水平，以检查不稳定心绞痛治疗前后的后续临床病程与血浆硫氧还蛋白水平之间的关系。对 44 名不稳定型心绞痛患者在入院时和治疗后进行了血液采样。此外，入院后还采集了41名稳定型劳力性心绞痛患者和41名胸痛综合征患者的血样。三组中不稳定心绞痛组的血浆硫氧还蛋白水平最高（p < 0.001）。不稳定型心绞痛的治疗降低了血浆硫氧还蛋白水平（p < 0.01）。我们根据入院时和治疗后血浆硫氧还蛋白水平将不稳定型心绞痛患者分为两组。通过带有 Yates 校正的 chi(2) 检验分析，入院时高硫氧还蛋白组和低硫氧还蛋白组之间的 Braunwald 分类存在显着差异（p < 0.05）。此外，通过 Yates 校正的 chi(2) 检验分析，治疗后高硫氧还蛋白组和低硫氧还蛋白组之间静息时心绞痛复发的发生率存在显着差异（p < 0.001）。本研究表明，与稳定型劳力性心绞痛和胸痛综合征患者相比，不稳定型心绞痛患者的血浆硫氧还蛋白水平显着升高。硫氧还蛋白水平与不稳定心绞痛患者复发性心肌缺血有关。 (c) 2004 Elsevier Ireland Ltd. 保留所有权利。
Plasma levels of human thioredoxin are indicative of the responses against oxidative stress. We measured the plasma thioredoxin levels in patients with unstable angina in order to examine the relationships between subsequent clinical course and plasma thioredoxin levels before and after treatment for unstable angina. Blood was sampled both on admission and after treatment in 44 patients with unstable angina. In addition, blood samples were obtained from 41 patients with stable exertional angina and 41 patients with chest pain syndrome after admission. The plasma levels of thioredoxin were the highest in the unstable angina group among three groups (p < 0.001). Treatment of unstable angina decreased the plasma thioredoxin levels (p < 0.01). We divided the patients with unstable angina into two groups according to the plasma thioredoxin levels on admission and after treatment. There was a significant difference in Braunwald's classification between the high thioredoxin and the low thioredoxin group on admission, as analyzed by the chi(2) test with Yates's correction (p < 0.05). Moreover, there was a significant difference in incidence of recurrent anginal attacks at rest between the high thioredoxin and the low thioredoxin group after treatment, as analyzed by the chi(2) test with Yates's correction (p < 0.001). The present study demonstrated that plasma thioredoxin levels are significantly increased in patients with unstable angina compared to those with stable exertional angina and chest pain syndrome. Thioredoxin levels were associated with recurrent myocardial ischemia in patients with unstable angina. (c) 2004 Elsevier Ireland Ltd. All rights reserved.