Iodine(III)-Mediated [3+2] Cyclization for One-Pot Synthesis of Benzo[d]isoxazole-4,7-diols in Aqueous Medium
Iodine(III)-Mediated [3+2] Cyclization for One-Pot Synthesis of Benzo[d]isoxazole-4,7-diols in Aqueous Medium
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碘(III)介导的[3 2]环化在水介质中一锅法合成苯并[d]异恶唑-4,7-二醇。
DOI：
10.1021/jo401077q
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发表时间：
2013-09-06
影响因子：
3.6
通讯作者：
Liu, Gang
中科院分区：
文献类型：
--
作者：
Hou, Yingwei;Lu, Shichao;Liu, Gang
以二醋酸碘苯为氧化剂，以腈氧化物和苯醌为中间体，在水介质中一锅[3 + 2]环添加剂合成了苯并[d]异恶唑-4,7-二醇。该方法还可用于合成经典方法难以获得的苯并二氮杂唑-4,8-二醇、异氮杂唑[5,4-a]非那嗪和茚唑-4,7-二醇。
A one-pot [3 + 2] cycloadditive synthesis of benzo[d]isoxazole-4,7-diols in aqueous medium was carried out via nitrile oxides and benzoquinone intermediates by taking advantage of iodobenzene diacetate as an oxidant. This method can also be used to synthesize benzodiisoxazole-4,8-diols, isoxazolo[5,4-a]phenazines, and indazole-4,7-diols, which are difficult to obtain by classical methods.