Rotating magnetic field-controlled fabrication of magnetic hydrogel with spatially disk-like microstructures
Rotating magnetic field-controlled fabrication of magnetic hydrogel with spatially disk-like microstructures
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DOI：
10.1007/s40843-017-9221-4
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发表时间：
2018-08-01
影响因子：
8.1
通讯作者：
Gu, Ning
中科院分区：
文献类型：
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作者：
Fan, Fengguo;Sun, Jianfei;Gu, Ning
具有可控微观结构的复合生物材料在组织工程和再生医学中发挥着越来越重要的作用。在这里，我们报告了一种具有盘状微结构的磁性水凝胶复合材料，其通过在旋转磁场存在的凝胶化过程中组装氧化铁纳米颗粒而制成。值得一提的是，这里的氧化铁纳米颗粒是按照 Ferumoxytol 的技术合成的，Ferumoxytol 是 FDA 批准用于临床的唯一无机纳米药物。由于磁性纳米颗粒排列链的扭曲，导致系统能量处于最低状态，因此水凝胶内纳米颗粒的微观结构是三维有序的。通过改变装配参数，微结构的尺寸可以从几微米到几十微米调整。随着微观结构尺寸的增加，磁热各向异性也随之增强。该结果证实，即使对于几微米的纳米粒子聚集体，也可以发生组装引起的各向异性。旋转磁场辅助技术对于制备具有有序微结构的复合水凝胶来说具有成本效益、简单且灵活的优点。相信这将有利于一些复合材料的快速、绿色、智能制造。
Composite biomaterials with controllable microstructures play an increasingly important role in tissue engineering and regenerative medicine. Here, we report a magnetic hydrogel composite with disk-like microstructure fabricated by assembly of iron oxide nanoparticles during the gelation process in the presence of rotating magnetic field. It should be mentioned that the iron oxide nanoparticles here were synthesized identically following techniques of Ferumoxytol that is the only inorganic nanodrug approved by FDA for clinical applications. The microstructure of nanoparticles inside the hydrogel was ordered three-dimensionally due to the twist of the aligned chains of magnetic nanoparticles which leads to the lowest state of systematic energy. The size of microstructure can be tuned from several micrometers to tens of micrometers by changing the assembly parameters. With the increase of microstructure size, the magnetothermal anisotropy was also augmented. This result confirmed that the assembly-induced anisotropy can occur even for the several micron aggregates of nanoparticles. The rotating magnetic field-assisted technique is cost-effective, simple and flexible for the fabrication of composite hydrogel with ordered microstructure. We believe it will be favorable for the quick, green and intelligent fabrication of some composite materials.