Primo Vascular System: An Endothelial-to-Mesenchymal Potential Transitional Tissue Involved in Gastric Cancer Metastasis.
Primo Vascular System: An Endothelial-to-Mesenchymal Potential Transitional Tissue Involved in Gastric Cancer Metastasis.
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Primo 血管系统：参与胃癌转移的内皮细胞到间质细胞的潜在过渡组织
DOI：
10.1155/2015/812354
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Soh KS
中科院分区：
文献类型：
--
作者：
Ping A;Zhendong S;Rongmei Q;Jingxing D;Wei C;Zhongyin Z;Hesheng L;Soh KS
胃癌是世界上第四常见的癌症，也是癌症相关死亡的第二大原因。胃癌转移的研究是肿瘤研究的热点和重点之一。越来越多的证据表明，初级血管系统（PVS）是继血管和淋巴系统之后的一种新型循环系统。以往的研究表明PVS是介于内皮和间质之间的特异性组织，与肿瘤的发生，尤其是肿瘤的转移和再生有关。本研究旨在探讨原发血管在胃癌转移中的作用及其与血管生成的可能关系。结果提示原发血管参与了胃癌的转移。我们观察到血管介导的转移，原发血管介导的转移，以及它们之间的中间状态。我们推测原始血管可能是血管的前身。这些结果可能为肿瘤转移的研究提供一个全新的理论发展。
Gastric cancer is the fourth commonest cancer in the world and the second leading cause of cancer-related death. Investigation of gastric cancer metastasis is one of the hottest and major focuses in cancer research. Growing evidence manifested that primo vascular system (PVS) is a new kind of circulatory system beyond vascular and lymphatic system. Previous researches revealed that PVS is a specific tissue between endothelium and mesenchyme and is involved in cancer, especially in tumor metastasis and regeneration. In current study, we investigated the role of primo vessels in gastric cancer metastasis and its possible relationship to vascular vessels formation. Our results indicated that primo vessels were involved in gastric cancer metastasis. We observed blood vessel-mediated metastasis, primo vessel-mediated metastasis, and an intermediate state between them. We deduced that primo vessels may be precursors of blood vessels. These results possibly provided a thoroughly new theoretic development in cancer metastasis.
DOI：
10.1155/2013/240168
发表时间：
2013
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
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作者：
Lee BC;Akers WJ;Jing X;Perez MI;Ryu Y
通讯作者：
Ryu Y