Hierarchies of NF-κB target-gene regulation.
Hierarchies of NF-κB target-gene regulation.
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DOI：
10.1038/ni.2070
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发表时间：
2011-07-19
影响因子：
30.5
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中科院分区：
文献类型：
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转录因子 NF-κB 家族的成员在几乎所有细胞类型中充当诱导基因表达的主要调节因子，以响应广泛的刺激，在协调先天免疫和适应性免疫方面发挥着特别重要的作用。这篇综述总结了阐明靶基因响应 NF-κB 诱导刺激的众多调控层的当前知识和最新进展。
Members of the NF-κB family of transcription factors function as dominant regulators of inducible gene expression in virtually all cell types in response to a broad range of stimuli, with particularly important roles in coordinating both innate and adaptive immunity. This review summarizes current knowledge and recent progress toward elucidating the numerous regulatory layers that confer target gene selectivity in response to an NF-κB-inducing stimulus.