Infant Leukemia and Congenital Abnormalities: A Children's Oncology Group Study
Infant Leukemia and Congenital Abnormalities: A Children's Oncology Group Study
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DOI：
10.1002/pbc.22495
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发表时间：
2010-07-15
影响因子：
3.2
通讯作者：
Ross, Julie A.
中科院分区：
文献类型：
--
作者：
Johnson, Kimberly J.;Roesler, Michelle A.;Ross, Julie A.
背景婴儿白血病是罕见的，除了年龄较大的儿童白血病外，还没有得到很好的研究。婴儿与大龄儿童白血病的生存率和分子特征的差异提示不同的病因，可能涉及产前因素。Procedure.我们在一项病例对照研究中检查了8类母亲报告的先天性异常（CA）（唇腭裂、脊柱裂或其他脊柱缺陷、大或多个胎记、其他染色体异常、小头或小头畸形、肋骨异常、泌尿生殖系统异常等）与婴儿白血病之间的关系。该研究包括443例确诊病例，
Background. Leukemia in infants is rare and has not been well studied apart from leukemia in older children. Differences in survival and the molecular characteristics of leukemia in infants versus older children suggest a distinct etiology, likely involving prenatal factors. Procedure. We examined the association between eight categories of maternally reported congenital abnormalities (CAs) (cleft lip or palate, spina bifida or other spinal defect, large or multiple birthmarks, other chromosomal abnormalities, small head or microcephaly, rib abnormalities, urogenital abnormalities, and other) and infant leukemia in a case-control study. The study included 443 cases diagnosed at