Shall we crosstalk? - The relationship between DNA methylation and histone H3 lysine 27 trimethylation.

Shall we crosstalk? - The relationship between DNA methylation and histone H3 lysine 27 trimethylation.
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DOI：
10.1002/bies.201300164
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发表时间：
2014
期刊：
Bioessays
影响因子：
4
通讯作者：
Kondo Y
Kondo Y
中科院分区：
生物学3区
文献类型：
--
作者：
Tahara T;Yamamoto E;Madireddi P;Suzuki H;Maruyama R;Chung W;Garriga J;Jelinek J;Yamano HO;Sugai T;Kondo Y;Toyota M;Issa JP;Estecio MR;Kondo Y

文献摘要

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作者评论了研究多梳阻遏复合物2（PRC2）为基础的组蛋白H3赖氨酸27三甲基化（H3K27me3）和DNA甲基化之间的关联。这两个表观遗传过程之间的关联对干细胞分化，肿瘤发生和体细胞编程的影响进行了概述。强调了理解表观遗传异常在癌症增强治疗策略发展中的重要性。
The author comments on the study examining the association between polycomb repressive complex 2 (PRC2)-based histone H3 lysine 27 trimethylation (H3K27me3) and DNA methylation. The implications of the association between the two epigenetic processes on stem cell differentiation, tumorigenesis and somatic cell programming are outlined. The significance of understanding epigenetic abnormalities in the development of enhanced therapeutic strategies for cancer is highlighted.