Zika Virus Infection with Prolonged Maternal Viremia and Fetal Brain Abnormalities
Zika Virus Infection with Prolonged Maternal Viremia and Fetal Brain Abnormalities
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DOI：
10.1056/nejmoa1601824
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发表时间：
2016-06-02
影响因子：
158.5
通讯作者：
Vapalahti, O.
中科院分区：
文献类型：
--
作者：
Driggers, R. W.;Ho, C. -Y.;Vapalahti, O.
目前寨卡病毒（ZIKV）感染的爆发与先天性小头畸形的风险明显增加有关。我们描述了一例孕妇及其胎儿在妊娠第11周感染ZIKV的病例。在妊娠16 ~ 20周，胎儿头围从第47百分位数下降到第24百分位数。在妊娠16周和21周时在母体血清中鉴定ZIKV RNA。在妊娠19周和20周时，超声检查和磁共振成像（MRI）检测到实质性脑异常，但不存在小头畸形或颅内钙化。在胎脑的尸检分析中，检测到弥漫性大脑皮质变薄、高ZIKV RNA载量和病毒颗粒，随后分离ZIKV。
The current outbreak of Zika virus (ZIKV) infection has been associated with an apparent increased risk of congenital microcephaly. We describe a case of a pregnant woman and her fetus infected with ZIKV during the 11th gestational week. The fetal head circumference decreased from the 47th percentile to the 24th percentile between 16 and 20 weeks of gestation. ZIKV RNA was identified in maternal serum at 16 and 21 weeks of gestation. At 19 and 20 weeks of gestation, substantial brain abnormalities were detected on ultrasonography and magnetic resonance imaging (MRI) without the presence of microcephaly or intracranial calcifications. On postmortem analysis of the fetal brain, diffuse cerebral cortical thinning, high ZIKV RNA loads, and viral particles were detected, and ZIKV was subsequently isolated.