Pregnancy and lactation mixed exposure to lead, cadmium, and mercury alters maternal-offspring single heavy metal load: A factorial design
Pregnancy and lactation mixed exposure to lead, cadmium, and mercury alters maternal-offspring single heavy metal load: A factorial design
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怀孕和哺乳期混合接触铅、镉和汞会改变母子单一重金属负荷：析因设计
DOI：
10.1016/j.ijheh.2023.114113
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发表时间：
2023
影响因子：
6
通讯作者：
Fan Guangqin
中科院分区：
文献类型：
--
作者：
Du Guihua;Zhou Fankun;Lu Ouyang;Wang Kai;Rao Shaoqi;Su Rui;Zhu Yanhui;Guo Kechu;Xiao Jinmei;Xie Jie;Li Qi;Feng Chang;Fan Guangqin
环境中暴露于铅 (Pb)、镉 (Cd) 和汞 (Hg) 的重金属混合物会对健康产生危害。然而，关于接触重金属混合物如何改变单个金属的代谢动力学的数据很少。考虑到剂量在决定重金属毒性方面起着关键作用，我们对低暴露水平下的三种重金属（Pb、Cd和Hg）进行了因子设计。雌性大鼠从成功交配到幼仔断奶期间均暴露于 Pb、Cd 和（或）Hg。测量了母体血液、母乳、出生后第 0 天 (PND0) 和 PND21 后代血液和全脑中的浓度。利用方差分析、皮尔逊相关和结构方程模型，我们证明了重金属在吸收、母子转运和靶器官积累过程中复杂的相互作用。在所有探索的样品中，几乎所有最高的 Pb、Cd 和 Hg 水平均在各自的单一重金属暴露组中观察到。此外，当铅或镉穿过胎盘屏障和血脑屏障（BBB）时，汞被发现可以拮抗它们的转运。然而，当汞被消化系统吸收后，汞的作用就不再显现。当Cd穿过胎盘屏障时，观察到Pb对Cd的拮抗作用。此外，还发现当Pb出生后穿过血脑屏障时，Cd会竞争Pb的转运途径。与Pb和Hg相比，我们发现Cd在消化系统中的转运效率较低，而胎盘屏障对Cd的螯合效果较好。这些初步信息可能有助于研究人员探索重金属混合物暴露危险影响的机制，或帮助监管机构修订重金属暴露指南。
Environmental exposure to heavy metal mixture of lead (Pb), cadmium (Cd), and mercury (Hg) would induce hazardous health effects. However, there is a paucity of data on how exposure to heavy metal mixture alters the metabolic dynamics of individual metals. Considering that the dose plays a key role in determining the toxicity of heavy metals, we performed a factorial design with three heavy metals (Pb, Cd, and Hg) at low exposure levels. Female rats were exposed to Pb, Cd, and (or) Hg from successful mating until pup weaning. Their concentrations in maternal blood, breast milk, and postnatal day 0 (PND0) and PND21 offspring blood and whole brain were measured. Using ANOVA analysis, Pearson correlation, and structural equation model, we demonstrated the complex interactions among heavy metals during their absorption, mother-offspring transport, and target organ accumulation. Among all the explored samples, almost all the highest Pb, Cd, and Hg levels were observed in their respective single heavy metal exposure groups. In addition, Hg was found could antagonize the transport of Pb or Cd, when they cross the placental barrier and blood-brain barriers (BBB). However, the effect of Hg no longer presented when they are absorbed through the digestive system. The antagonistic effect of Pb on Cd was observed when they cross the placental barrier. In addition, Cd was also found to compete the transport pathway of Pb when they cross the BBB after birth. Compared to Pb and Hg, we found that the transport efficiency of Cd in the digestive system was lower, whereas the chelation of Cd by the placental barrier was better. This preliminary information may help researchers to explore the mechanism underlying the hazardous effects of heavy metal mixture exposure, or for regulatory agencies to revise guidelines for heavy metal exposure.