Stem cell transplantation therapy in Parkinson's disease.
Stem cell transplantation therapy in Parkinson's disease.
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DOI：
10.1186/s40064-015-1400-1
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Yang SH
中科院分区：
文献类型：
--
作者：
Fu MH;Li CL;Lin HL;Chen PC;Calkins MJ;Chang YF;Cheng PH;Yang SH
中枢神经系统的无效治疗和修复能力不足是几种神经系统疾病的令人不安的问题。幸运的是，临床上可应用的干细胞群的发展为克服内源性修复系统的失败和将新细胞替代到受损的大脑中提供了一条途径。然而，转化为临床应用仍然存在一些现有的障碍。在这里，我们回顾了帕金森病的干细胞治疗，并讨论了潜在的优点和缺点。我们希望这篇综述可以为克服目前与干细胞在帕金森病中的应用相关的技术和生物学问题提供可行的策略建议。
Ineffective therapeutic treatments and inadequate repair ability in the central nervous system are disturbing problems for several neurological diseases. Fortunately, the development of clinically applicable populations of stem cells has provided an avenue to overcome the failure of endogenous repair systems and substitute new cells into the damaged brain. However, there are still several existing obstacles to translating into clinical application. Here we review the stem-cell based therapies for Parkinson’s disease and discuss the potential advantages and drawbacks. We hope this review may provide suggestions for viable strategies to overcome the current technical and biological issues associated with the application of stem cells in Parkinson’s disease.