Differential Columnar Processing in Local Circuits of Barrel and Insular Cortices
Differential Columnar Processing in Local Circuits of Barrel and Insular Cortices
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DOI：
10.1523/jneurosci.0172-08.2008
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发表时间：
2008-03
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通讯作者：
Hajime Sato;Y. Shimanuki;M. Saito;H. Toyoda;T. Nokubi;Y. Maeda;Takamichi Yamamoto;Youngnam Kang
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文献类型：
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作者：
Hajime Sato;Y. Shimanuki;M. Saito;H. Toyoda;T. Nokubi;Y. Maeda;Takamichi Yamamoto;Youngnam Kang
柱状组织在须桶皮层中最明显，但在味觉岛皮层中似乎不太明显。我们在这里讨论是否有任何差异，两个皮质之间的柱状信息处理，通过比较的时空模式的兴奋扩散在两个皮质使用电压敏感染料成像。与由IV层刺激在桶状皮层中诱导的II/III层中水平方向上的众所周知的兴奋传播相反，由IV层刺激在岛状皮层中引起的兴奋在垂直方向上双向传播到II/III层和V/VI层中，显示柱状图像图案。荷包牡丹碱或印防己毒素显着延长了水平的兴奋传播在第II/III层的桶皮质，导致在底层V/VI的激发的产生，而那些显着增加了整个列在岛叶皮质的光学响应的幅度，随后扩大了柱状图像图案。这种同步活动所揭示的水平和垂直的兴奋传播一致诱导桶和岛叶皮层，分别，即使不同层次的刺激强度不同。因此，一个独特的功能柱存在于岛皮质，其中柱内沟通的浅，深层之间是突出的，和GABAA的行动是参与抑制柱内通信相反，它参与柱间侧抑制在桶皮质。这些结果表明，柱状信息处理可能不是通用的不同的皮层区域。
The columnar organization is most apparent in the whisker barrel cortex but seems less apparent in the gustatory insular cortex. We addressed here whether there are any differences between the two cortices in columnar information processing by comparing the spatiotemporal patterns of excitation spread in the two cortices using voltage-sensitive dye imaging. In contrast to the well known excitation spread in the horizontal direction in layer II/III induced in the barrel cortex by layer IV stimulation, the excitation caused in the insular cortex by stimulation of layer IV spread bidirectionally in the vertical direction into layers II/III and V/VI, displaying a columnar image pattern. Bicuculline or picrotoxin markedly extended the horizontal excitation spread in layer II/III in the barrel cortex, leading to a generation of excitation in the underlying layer V/VI, whereas those markedly increased the amplitude of optical responses throughout the whole column in the insular cortex, subsequently widening the columnar image pattern. Such synchronous activities as revealed by the horizontal and vertical excitation spreads were consistently induced in the barrel and insular cortices, respectively, even by stimulation of different layers with varying intensities. Thus, a unique functional column existed in the insular cortex, in which intracolumnar communication between the superficial and deep layers was prominent, and GABAA action is involved in the inhibition of the intracolumnar communication in contrast to its involvement in intercolumnar lateral inhibition in the barrel cortex. These results suggest that the columnar information processing may not be universal across the different cortical areas.