Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer.
Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer.
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DOI：
10.1016/j.stem.2015.08.014
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发表时间：
2015-09-03
期刊：
影响因子：
23.9
通讯作者：
Wicha MS
中科院分区：
文献类型：
--
作者：
Brooks MD;Burness ML;Wicha MS
细胞异质性是癌症治疗中最大的挑战之一。在许多恶性肿瘤中，这种异质性是在肿瘤演变过程中通过遗传改变和表观遗传事件的组合产生的，表观遗传事件概括了正常的发育过程，包括干细胞自我更新和分化。许多（如果不是大多数的话）肿瘤显示出类似的分层组织，在其顶端是“干细胞样细胞”，其驱动肿瘤生长，介导转移并有助于治疗抗性。以乳腺癌为模型，我们讨论了如何更好地了解肿瘤细胞的异质性和可塑性可能导致更有效的治疗策略的发展。
Cellular heterogeneity represents one of the greatest challenges in cancer therapeutics. In many malignancies, this heterogeneity is generated during tumor evolution through a combination of genetic alterations and epigenetic events that recapitulate normal developmental processes including stem cell self-renewal and differentiation. Many, if not most, tumors display similar hierarchal organization, at the apex of which are “stem-like cells” that drive tumor growth, mediate metastasis and contribute to treatment resistance. Using breast cancer as a model, we discuss how an improved understanding of tumor cellular heterogeneity and plasticity may lead to development of more effective therapeutic strategies.