The Acetyltransferase CLOCK Is Dispensable for Circadian Aftereffects in Mice
The Acetyltransferase CLOCK Is Dispensable for Circadian Aftereffects in Mice
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DOI：
10.1177/0748730411416329
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发表时间：
2011-12-01
影响因子：
3.5
通讯作者：
Cheng, Hai-Ying M.
中科院分区：
文献类型：
--
作者：
Beaule, Christian;Cheng, Hai-Ying M.
最近对Clock基因的组蛋白乙酰转移酶活性的研究，极大地扩展了生物钟在基因转录中的调节作用。Clock和它的伙伴Bmal1负责产生与外部光周期同步的昼夜节律振荡。携带光通常会在内源性期间产生持久的变化，称为后效。后遗症是在光照射终止后持续数周的自由运行节奏的速度依赖于光的改变。光如何引起如此持久的变化尚不清楚。然而，昼夜节律后效的持续性，以及表观遗传修饰对发育和脑生理各方面的长期影响，促使我们假设组蛋白乙酰转移酶CLOCK是昼夜节律后效所必需的。作者将敲除Clock的小鼠暴露在25小时的光周期中，并报告说这些小鼠保留了显示昼夜节律后效的能力，这表明Clock对于这种形式的昼夜节律可塑性是不可或缺的。
Recent demonstration of the histone acetyltransferase activity of the Clock gene greatly expanded the regulatory role of circadian clocks in gene transcription. Clock and its partner Bmal1 are responsible for the generation of circadian oscillations that are synchronized (entrained) to the external light cycle. Entraining light often produces long-lasting changes in the endogenous period called aftereffects. Aftereffects are light-dependent alterations in the speed of free-running rhythms that persist for several weeks upon termination of light exposure. How light causes such long-lasting changes is unknown. However, the persistent nature of circadian aftereffects in conjunction with the long-term effects of epigenetic modifications on development and various aspects of brain physiology prompted us to hypothesize that the histone acetyltransferase CLOCK was required for circadian aftereffects. The authors exposed Clock knockout mice to 25-hour light cycles and report that these mice retain the ability to display circadian aftereffects, indicating that Clock is dispensable for this form of circadian plasticity.