Smart polymer based delivery systems for peptides and proteins.
Smart polymer based delivery systems for peptides and proteins.
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DOI：
10.2174/187221107779814113
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发表时间：
2007-01-01
影响因子：
--
通讯作者：
Singh, Jagdish
中科院分区：
文献类型：
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作者：
Al-Tahami, Khaled;Singh, Jagdish
可生物降解的聚合物系统代表了输送许多生物活性剂（包括肽和蛋白质药物）的有前途的方法。随着对肽和蛋白质药理学的理解以及大规模生产这些化合物的能力的进步，这些系统的重要性与日俱增。一些聚合物一旦施用就会发生溶胶-凝胶转变。原位凝胶形成是对一种刺激或两种或更多种刺激的组合作出反应而发生的。这些刺激包括紫外线照射、pH 值变化、温度变化和溶剂交换。与传统方法相比，这些智能聚合物系统具有多种优点，例如易于制造、易于给药、生物可降解性以及改变所掺入药物的释放曲线的能力。在过去的几年中，人们对越来越多的原位凝胶形成系统进行了研究，并报道了它们在各种生物医学应用（包括药物输送）中的使用的许多专利。在本文中，我们介绍了使用智能聚合物输送肽和蛋白质药物已开发并获得专利的不同策略。讨论了每种智能聚合物系统的优点、缺点、可能性和局限性。
Biodegradable polymeric systems represent promising means for delivering many bioactive agents, including peptide and protein drugs. The importance of these systems grew with the advancement in the understanding of peptide and protein pharmacology as well as the ability to mass-produce these compounds. Some polymers undergo sol-gel transition once administered. In situ gel formation happens in response to one or a combination of two or more stimuli. These stimuli include UV-irradiation, pH change, temperature change, and solvent exchange. These smart polymeric systems have several advantages over conventional methods, such as ease of manufacturing, ease of administration, biodegradability, and the ability to alter release profiles of the incorporated agents. In the past few years, an increasing number of in situ gel-forming systems have been investigated and many patents for their use in various biomedical applications, including drug delivery, have been reported. In this article, we introduce the different strategies that have been developed and patented for the use of smart polymers in delivering peptide and protein drugs. The advantage, disadvantages, possibilities, and limitations of each of the smart polymer systems have been discussed.