Anxiety traits associated with a polymorphism in the serotonin transporter gene regulatory region in the Japanese
Anxiety traits associated with a polymorphism in the serotonin transporter gene regulatory region in the Japanese
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DOI：
10.1007/s100380050098
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发表时间：
1999-01-01
影响因子：
3.5
通讯作者：
Adachi, K
中科院分区：
文献类型：
--
作者：
Murakami, F;Shimomura, T;Adachi, K
我们使用Lesch等人的聚合酶链反应测定了501名健康日本人5-羟色胺（5-HT）转运蛋白基因连锁多态性区域（5-HTTLPR）的多态性，但作了微小的修改。等位基因频率的分布进行了测定，发现不同的高加索人。我们还调查了5-HTTLPR多态性与焦虑特质的关系，501名受试者中有189名完成了焦虑和抑郁的自评问卷。短/短（s/s）基因型的受试者的焦虑评分显著高于长/长（l/l）或l/s基因型的受试者。结果表明，5-HTTLPR基因s/s型人群比l型人群具有更强的焦虑相关人格特征。
We determined polymorphism in the serotonin (5-HT) transporter gene-linked polymorphic region (5-HTTLPR) in 501 healthy Japanese, individuals, using the polymerase chain reaction of Lesch et al., with minor modifications. The distribution of allele frequencies was determined and found to differ from that in Caucasians. We also investigated the relationship of polymorphism in 5-HTTLPR to anxiety traits, by having 189 of the 501 subjects complete a self-rating questionnaire for anxiety and depression. Subjects with the short/short (s/s) genotype had significantly higher anxiety scores than those with the long/long (l/l) or l/s genotype. It is suggested that populations with the s/s genotype of 5-HTTLPR have stronger anxiety-related personality traits than those with the l allele.