Extracellular matrix components in breast carcinomas
Extracellular matrix components in breast carcinomas
复制标题
DOI：
10.1016/s1044-579x(02)00027-5
复制
发表时间：
2002-06-01
影响因子：
14.5
通讯作者：
Robert, L
中科院分区：
文献类型：
--
作者：
Kadar, A;Tokés, AM;Robert, L
恶性过程干扰细胞外基质生物合成的正常“程序”，并且可以广泛地改变基质的结构和组成。薄效应似乎可归因于几个过程，例如恶性细胞直接产生某些选定的基质大分子或间接产生干扰正常基质产生的恶性细胞因子。也可能存在其他可能性，例如环境致癌物的直接作用，否则正常的间充质细胞。其结果是组织结构和组成的或多或少的深刻改变，并对恶性过程产生可能的反馈效应。一些例子将被讨论，如弹性蛋白生产的一些肿瘤，以及生物合成的一些其他选定的基质大分子，如生腱蛋白和骨桥蛋白的乳腺肿瘤。虽然这些特定基质产生的详细机制尚未完全阐明，但对特定基质产生过程的调控和无序基质产生的快速增长的知识可能代表癌症研究和基质生物学之间的新领域。
A malignant process interferes with the normal 'programme' of extracellular matrix biosynthesis and can modify, extensively the structure and composition of the matrix. Thin effect appears to be attributable to several processes such as direct production of some selected matrix macromolecules by, malignant cells or indirectly by the production of factors malignant cells interfering with the regulation of normal matrix production. Other possibilities may also exist, such as the direct action of an environment carcinogen otherwise normal mesenchymal cells. The result is a more or less profound modification of tissue structure and composition with possible feedback effects on the malignant process. Some examples will be discussed such as elastin production by some tumours as well as the biosynthesis of some other selected matrix macromolecules as tenascin and osteopontin by breast tumours. Although the detailed mechanisms of these specific matrix productions is not yet completely elucidated, the rapidly increasing knowledge on the regulation of specific matrix production process and deranged matrix production might represent a new area of crosstalk between cancer research and matrix biology.