PA28γ, an Accomplice to Malignant Cancer.
PA28γ, an Accomplice to Malignant Cancer.
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PA28γ，恶性肿瘤的帮凶
DOI：
10.3389/fonc.2020.584778
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发表时间：
2020
影响因子：
4.7
通讯作者：
Chen Q
中科院分区：
文献类型：
--
作者：
Lei K;Bai H;Sun S;Xin C;Li J;Chen Q
PA28γ是20S蛋白酶体的核激活剂，参与一些基本细胞过程和血管生成的调节。在过去的20年里，许多氨基酸位点和基序被证明在PA28γ的特征功能中起着重要作用。PA28γ的结合伙伴数量和已验证的细胞功能增加，这有助于澄清其参与不同的生物事件。PA28γ参与多种疾病的进展，其在癌症中的异常过表达是值得注意的。PA28γ表达水平低的患者比PA28γ表达水平高的患者生存率更高，这在多种肿瘤中都得到了证实。PA28γ在肿瘤中的功能可分为细胞增殖、细胞凋亡、转移与侵袭、与血管生成相关的细胞核动力学、病毒感染等五大类。本文就PA28γ在癌症中的作用进行综述，总结其在各种癌症中的异常表达、致癌作用及其机制，并重点介绍PA28γ在癌症诊断、靶向治疗和预后评估等方面的潜在应用。
PA28γ is a nuclear activator of the 20S proteasome, which is involved in the regulation of several essential cellular processes and angiogenesis. Over the past 20 years, many amino acid sites and motifs have been proven to play important roles in the characteristic functions of PA28γ. The number of binding partners and validated cellular functions of PA28γ have increased, which has facilitated the clarification of its involvement in different biological events. PA28γ is involved in the progression of various diseases, and its aberrant overexpression in cancer is remarkable. Patients with low levels of PA28γ expression have a higher survival rate than those with high levels of PA28γ expression, as has been shown for a wide variety of tumors. The functions of PA28γ in cancer can be divided into five main categories: cell proliferation, cell apoptosis, metastasis and invasion, cell nuclear dynamics that have relevance to angiogenesis, and viral infection. In this review, we focus on the role of PA28γ in cancer, summarizing its aberrant expression, prooncogenic effects and underlying mechanisms in various cancers, and we highlight the possible cancer-related applications of PA28γ, such as its potential use in the diagnosis, targeted treatment and prognostic assessment of cancer.
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影响因子：
--
作者：
Kato, Koichi;Satoh, Tadashi
通讯作者：
Satoh, Tadashi
影响因子：
4.8
作者：
Liu, Jiang;Wang, Ying;Li, Xiaotao
通讯作者：
Li, Xiaotao
PA28γ 作为 IL-6 和 CCL2 的双重调节剂，有助于口腔鳞状细胞癌中的肿瘤血管生成。
影响因子：
9.7
作者：
Liu, Sai;Liu, Dongjuan;Chen, Qianming
通讯作者：
Chen, Qianming
DOI：
10.1073/pnas.1722299115
发表时间：
2018-07-10
影响因子：
11.1
作者：
Jonik-Nowak B;Menneteau T;Fesquet D;Baldin V;Bonne-Andrea C;Méchali F;Fabre B;Boisguerin P;de Rossi S;Henriquet C;Pugnière M;Ducoux-Petit M;Burlet-Schiltz O;Lamond AI;Fort P;Boulon S;Bousquet MP;Coux O
通讯作者：
Coux O
蛋白酶体激活剂 PA28γ 与口腔鳞状细胞癌结果之间的关联：来自队列研究和功能分析的证据。
影响因子：
11.1
作者：
Li J;Feng X;Sun C;Zeng X;Xie L;Xu H;Li T;Wang R;Xu X;Zhou X;Zhou M;Zhou Y;Dan H;Wang Z;Ji N;Deng P;Liao G;Geng N;Wang Y;Zhang D;Lin Y;Ye L;Liang X;Li L;Luo G;Jiang L;Wang Z;Chen Q
通讯作者：
Chen Q