Novel Pt(II) and Pd(II) complexes with polyamine analogues: synthesis and vibrational analysis.
Novel Pt(II) and Pd(II) complexes with polyamine analogues: synthesis and vibrational analysis.
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新型 Pt(II) 和 Pd(II) 与多胺类似物的配合物：合成和振动分析。
DOI：
10.1016/j.jinorgbio.2011.11.021
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发表时间：
2012
影响因子：
3.9
通讯作者：
Marques,MPM
中科院分区：
文献类型：
--
作者：
Silva,TM;Oredsson,S;Persson,L;Woster,P;Marques,MPM
报道了生物多胺类似物去甲精胺(NSPD)、N1，N11-二(乙基)去甲精胺(BENSpm)和N1-环丙基甲基-N11-乙基去甲精胺(CPENSpm)及其新合成的铂(II)和钯(II)配合物的振动光谱(红外光谱和拉曼光谱)。考虑到这类系统潜在的抗肿瘤特性，它们的完整构象表征对于了解它们的细胞毒活性的分子基础和它们被转运到细胞内的机制是必不可少的。全反式构型对所有完全质子化的烷基化多胺都是有利的，而它们的多核络合物呈现出与先前得到的类似亚精胺(M3Spd2)和精胺(M2Spm)的类似的构型非常相似的稳定构型，包括两个或三个类顺铂(MCl2NH2)部分。
A vibrational spectroscopy study (infrared and Raman) is reported for the biogenic polyamine analogues norspermidine (NSpd), N1,N11-bis(ethyl)norspermine (BENSpm) and N1-cyclo-propylmethyl-N11-ethylnorspermine (CPENSpm), as well as for their newly synthesised Pt(II) and Pd(II) complexes. Attending to the potential antineoplastic properties of this kind of systems, their full conformational characterization is essential for understanding the molecular basis of their cytotoxic activity and the mechanisms through which they are transported into the cell. The all-trans geometry was found to be favoured for all the alkylated polyamines, in their totally protonated state, while their polynuclear complexes presented a stable geometry very similar to that previously obtained for the analogous chelates with spermidine (M3Spd2) and spermine (M2Spm), comprising two or three cisplatin-like (MCl2NH2) moieties.