Prolactin responses to neuroleptics in normal and schizophrenic subjects.
Prolactin responses to neuroleptics in normal and schizophrenic subjects.
复制标题
正常和精神分裂症受试者中催乳素对精神安定药的反应。
DOI：
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发表时间：
1978
影响因子：
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通讯作者：
F. Halpern
中科院分区：
文献类型：
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作者：
P. Gruen;E. Sachar;G. Langer;N. Altman;M. Leifer;A. Frantz;F. Halpern
催乳素对抗精神病药的反应可以作为人类多巴胺阻断的一个指标。在正常和精神分裂症受试者中，单剂量氯丙嗪的血浆催乳素增量和单剂量左旋多巴的血浆催乳素减少量相似。所有化学类抗精神分裂症药物均刺激催乳素释放，而化学相关药物和其他精神药物对精神分裂症无效。所有患者对抗精神病药物治疗均有催乳素反应，且未产生耐受性。在受试者中，催乳素反应根据抗精神病药剂量分级，但反应曲线的灵敏度上限是在剂量低于治疗范围时达到的。氯丙嗪、噻嗪、三氟拉嗪、丁哌嗪和氟哌啶醇在人体内的相对催乳素效价与它们的相对临床效价具有良好的相关性。
The prolactin response to neuroleptics can serve as an index of dopamine blockade in humans. Plasma prolactin increments to single doses of chlorpromazine, and prolactin decrements to single doses of levodopa, were similar in normal and schizophrenic subjects. Antischizophrenic drugs of all chemical classes stimulated prolactin release,while chemically related drugs and other psychotropic agents ineffective in schizophrenia did not. The prolactin response to neuroleptic therapy occurred in all patients, and tolerance did not develop. Within subjects, prolactin responses were graded according to neuroleptic dose, but the upper limit of sensitivity of the response curve was achieved at doses below the therapeutic range. Relative prolactin-stimulating potency in humans of chlorpromazine, thioridazine, trifluoperazine, butaperazine, and haloperidol correlated well with their relative clinical potencies.