Suppression of intestinal polyp development by nimesulide, a selective cyclooxygenase-2 inhibitor, in Min mice
Suppression of intestinal polyp development by nimesulide, a selective cyclooxygenase-2 inhibitor, in Min mice
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DOI：
10.1111/j.1349-7006.1997.tb00337.x
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发表时间：
1997-12-01
期刊：
影响因子：
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通讯作者：
Wakabayashi, K
中科院分区：
文献类型：
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作者：
Nakatsugi, S;Fukutake, M;Wakabayashi, K
非甾体抗炎药（NSAIDs）抑制人类和实验动物结肠癌的发生。然而，传统的非甾体抗炎药抑制环加氧酶（COX）异构体COX-1和COX-2，并引起胃肠道副作用。尼美苏利是一种COX-2的选择性抑制剂，它的溃疡性要小得多，因此，我们研究了它对Min小鼠肠息肉发展的影响，4周龄的雌性Rlin小鼠在11周的饮食中给予400ppm的尼美苏利，这种治疗导致小肠和大肠息肉的数量显著减少，总数是未治疗的对照Min小鼠的52%。尼美舒利治疗组的息肉体积明显减小，提示尼美舒利是一种低毒性的人类结肠癌化学预防药物。
Nonsteroidal anti-inflammatory drugs (NSAIDs) suppress colon carcinogenesis in man and experimental animals. However, conventional NSAIDs inhibit both cyclooxygenase (COX) isoforms, COX-1 and COX-2, and cause gastrointestinal side-effects. Nimesulide, a selective inhibitor of COX-2, is much less ulcerogenic, We, therefore, examined its influence on the development of intestinal polyps in Min mice, Female Rlin mice at 4 weeks old were given 400 ppm nimesulide in their diet for 11 weeks, This treatment resulted in a significant reduction of the numbers of both small and large intestinal polyps, the total being 52% of that in untreated control Min mice, The size of the polyps in the nimesulide-treated group was also significantly decreased, The results suggest that nimesulide is a good candidate as a chemopreventive agent for human colon cancer with low toxicity.