The role of RANTES in meningococcal disease
The role of RANTES in meningococcal disease
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DOI：
10.1086/315680
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发表时间：
2000-07-01
影响因子：
6.4
通讯作者：
Hart, CA
中科院分区：
文献类型：
--
作者：
Carrol, ED;Thomson, APJ;Hart, CA
趋化因子RANTES（受激活调节，正常T细胞表达和分泌）是白细胞运输的有效调节剂。RANTES优先吸引成熟的CD 4细胞以及巨噬细胞和嗜酸性粒细胞，但不吸引中性粒细胞。总共对128名脑膜炎球菌病儿童进行了前瞻性研究，并评估了RANTES在脑膜炎球菌病病理生理学中的作用。入院时检测血浆RANTES、白细胞介素（IL）-8、IL-6、IL-1受体激动剂和肿瘤坏死因子-a。根据格拉斯哥脑膜炎球菌败血症预后评分（GMSPS）对疾病的严重程度进行分层。RANTES水平与IL-8水平、入院乳酸水平、血小板、凝血酶原时间和活化部分凝血活酶时间显著相关。RANTES水平在重症患儿（GMSPS大于或等于8; P = 0.001）、感染性休克患儿（P <0.0005）和死亡患儿（P = 0.048; Mann-Whitney检验）中较低。RANTES是脑膜炎球菌病病理生理学的潜在介质。
The chemokine RANTES (regulated on activation, normal T cell expressed and secreted) is a potent regulator of leukocyte trafficking. RANTES preferentially attracts mature CD4 cells as well as macrophages and eosinophils, but not neutrophils. In total, 128 children with meningococcal disease were prospectively studied, and the role of RANTES in the pathophysiology of meningococcal disease was assessed. Plasma RANTES, interleukin (IL)-8, IL-6, IL-1 receptor agonist, and tumor necrosis factor-a were measured at admission. Severity of disease was stratified by the Glasgow meningococcal septicemia prognostic score (GMSPS). RANTES levels correlated significantly with IL-8 levels, admission lactate levels, platelets, prothrombin time, and activated partial thromboplastin time. RANTES levels were lower in children with severe disease (GMSPS greater than or equal to 8; P = .001), in those with septic shock (P < .0005), and in nonsurvivors (P = .048; Mann-Whitney test). RANTES is a potential mediator in the pathophysiology of meningococcal disease.