Three cases of IMP-type metallo-β-lactamase-producing Enterobacter cloacae bloodstream infection in Japan
Three cases of IMP-type metallo-β-lactamase-producing Enterobacter cloacae bloodstream infection in Japan
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DOI：
10.1007/s10156-012-0520-6
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发表时间：
2013-10-01
影响因子：
2.2
通讯作者：
Ohmagari, Norio
中科院分区：
文献类型：
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作者：
Hamada, Yohei;Watanabe, Koji;Ohmagari, Norio
我们报告了三例IMP型金属β-内酰胺酶产生的阴沟肠杆菌血流感染，这表明亚胺培南的最低抑菌浓度值为2 μ g/ml的所有菌株。尽管在所有病例中均凭经验开始使用碳青霉烯类，但三例病例中有两例死亡。临床和实验室标准研究所在2010年降低了碳青霉烯类抗生素对肠杆菌科的断点。然而，许多临床实验室仍然使用以前的折点，这可能导致无法检测到碳青霉烯类耐药肠杆菌科。因此，在临床环境中应使用较低的碳青霉烯类抗生素折点，检测金属β-内酰胺酶的替代检测方法，如聚合酶链反应和免疫色谱法，可能有助于更好地检测碳青霉烯类抗生素耐药菌株。
We report three cases of IMP-type metallo-beta-lactamase-producing Enterobacter cloacae bloodstream infection, which showed minimum inhibitory concentration values for imipenem with 2 mu g/ml in all isolates. Although carbapenems were initiated empirically in all cases, two of three cases died. The Clinical and Laboratory Standards Institute lowered the breakpoints of carbapenems for Enterobacteriaceae in 2010. However, the previous breakpoints are still used in many clinical laboratories, which can result in failure to detect carbapenem-resistant Enterobacteriaceae. Therefore, lower breakpoints of carbapenems should be used in clinical settings, and alternative tests for detecting metallo-beta-lactamase such as polymerase chain reaction and immunochromatographic assays may contribute to better detection of carbapenem-resistant isolates.