Medical-grade honey kills antibiotic-resistant bacteria in vitro and eradicates skin colonization
Medical-grade honey kills antibiotic-resistant bacteria in vitro and eradicates skin colonization
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DOI：
10.1086/587892
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发表时间：
2008-06-01
影响因子：
11.8
通讯作者：
Zaat, Sebastian A. J.
中科院分区：
文献类型：
--
作者：
Kwakman, Paulus H. S.;Van den Akker, Johannes P. C.;Zaat, Sebastian A. J.
Background. Antibiotic resistance among microbes urgently necessitates the development of novel antimicrobial agents. Since ancient times, honey has been used successfully for treatment of infected wounds, because of its antibacterial activity. However, large variations in the in vitro antibacterial activity of various honeys have been reported and hamper its acceptance in modern medicine.Methods. We assessed the in vitro bactericidal activity of Revamil (Bfactory), a medical-grade honey produced under controlled conditions, and assessed its efficacy for reduction of forearm skin colonization in healthy volunteers in a within-subject-controlled trial.Results. With Bacillus subtilis as a test strain, we demonstrated that the variation in bactericidal activity of 11 batches of medical-grade honey was
