Prognostic significance of GPC5 expression in patients with prostate cancer
Prognostic significance of GPC5 expression in patients with prostate cancer
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GPC5表达在前列腺癌患者中的预后意义
DOI：
10.1007/s13277-015-4499-3
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Zhang Zhihong
中科院分区：
文献类型：
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作者：
Zhang Changwen;Liu Zhifei;Wang Li;Qiao Baomin;Du E.;Li Li;Xu Yong;Zhang Zhihong
本研究旨在探讨磷脂酰肌醇蛋白聚糖-5（GPC 5）在前列腺癌中的表达及其与临床病理的关系。采用免疫组织化学方法检测160例前列腺癌组织和60例癌旁正常组织中GPC 5蛋白的表达，并将其与临床病理参数进行相关性分析。GPC 5在前列腺癌组织中的表达明显低于正常前列腺组织，尤其是在高危前列腺癌组织中。此外，GPC 5的低表达与血清前列腺特异性抗原（PSA）升高、Gleason评分升高、肿瘤分期（T3）晚期、淋巴结转移阳性和生化复发密切相关。此外，GPC 5低表达是前列腺癌患者总生存期的独立预后因素。GPC 5蛋白表达与前列腺癌的发生、发展密切相关，有望成为前列腺癌诊断和预后预测的新生物标志物。
The objective of this study was to evaluate the protein level of glypican-5 (GPC5) and its relationship with clinicopathologic significance in prostate cancer. The protein level of GPC5 in 160 prostate cancer tissues and 60 adjacent normal samples was examined by immunohistochemistry analysis, and the results were correlated with clinicopathologic parameters. The level of GPC5 in prostate cancer tissues was markedly lower than that in normal cases, especially in high-risk prostate cancer. Additionally, the low expression of GPC5 was closely associated with increased serum prostate-specific antigen (PSA), higher Gleason scores, advanced tumor stage (T3), positive lymph node metastasis, and biochemical recurrence. Moreover, GPC5 low expression was an independent prognostic factor for overall survival of patients with prostate cancer. GPC5 protein expression showed a close correlation with the tumorigenesis and tumor progression of prostate cancer, and that might be applied as a novel biomarker for the prediction of diagnosis and prognosis of prostate cancer.