Interferons and their use in persistent viral infections.
Interferons and their use in persistent viral infections.
复制标题
DOI：
10.1007/978-3-540-79086-0_8
复制
发表时间：
2009
影响因子：
--
通讯作者：
Pawlotsky JM
中科院分区：
文献类型：
--
作者：
Chevaliez S;Pawlotsky JM
2007年，世界庆祝了Isaacs和Lindenmann发现干扰素（IFN）50周年。随后，IFN-α基因被克隆，完全测序，并以重组形式产生IFN-α。重组IFN-α目前被用作治疗慢性丙型肝炎病毒感染的基础，也可用于治疗某些形式的慢性B型肝炎病毒感染。干扰素也被用于其他病毒感染，尽管成功率较低。本章综述了干扰素的抗病毒机制以及干扰素在治疗持续性病毒感染中的应用。
In 2007, the world celebrated the 50th anniversary of the discovery of interferon (IFN) by Isaacs and Lindenmann. Subsequently, the IFN-α gene was cloned, fully sequenced and IFN-α was produced in recombinant form. Recombinant IFN-α is now used as the basis for treatment of chronic hepatitis C virus infection and can also be used to treat certain forms of chronic hepatitis B virus infections. IFNs have also been used in other viral infections, although with less success. The antiviral mechanisms of IFNs are reviewed in this chapter as well as the utility of IFNs in the treatment of persistent viral infections.