Placental Growth during Normal Pregnancy - A Magnetic Resonance Imaging Study
Placental Growth during Normal Pregnancy - A Magnetic Resonance Imaging Study
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DOI：
10.1159/000452661
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发表时间：
2017-01-01
影响因子：
2.1
通讯作者：
Vejlstrup, Niels
中科院分区：
文献类型：
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作者：
Langhoff, Lasse;Gronbeck, Lene;Vejlstrup, Niels
目的：使用 MRI 纵向研究正常人类胎盘在妊娠中期和晚期的生长情况。方法：对 20 名正常的首次单胎妊娠在妊娠第 14 周至第 38 周期间使用 MRI 进行 7 次扫描，间隔 4 周。在矢状切片和横向切片中测量胎盘体积。分娩后对所有胎盘进行称重以进行比较研究。结果：20 名女性中有 16 名在妊娠第 14 周至第 38 周期间胎盘体积增大。第6次和第7次扫描显示，4名女性的胎盘大小相同。平均胎盘体积从妊娠第 14 周到第 38 周线性增加，平均增长率恒定为 29.97 毫升/周。外推至分娩时的中位胎盘体积为 856 毫升（范围 602-1,050 毫升）。分娩后放血胎盘的中位重量为 640 克（范围 500-787 克）。所有妊娠均足月，产下健康婴儿，胎盘大小和出生体重之间具有良好的相关性（R = 0.56，p = 0.009）。结论：在一项纵向研究中，使用 MRI 系统地测量了妊娠中期和晚期的胎盘生长情况。 MRI 提供了一种安全可行的测量胎盘生长的方法。在整个妊娠中期和晚期，平均胎盘生长呈线性。 (C) 2016 S. Karger AG，巴塞尔
Objective: To investigate normal human placental growth longitudinally throughout the second and third trimesters using MRI. Methods: Twenty normal, first-time singleton pregnancies were scanned 7 times between the 14th and 38th week of gestation, at 4-week intervals, using MRI. Placental volumes were measured in both sagittal and transversal slices. All placentas were weighed after delivery to make a comparative study. Results: Sixteen of the 20 women had increasing placental volumes from the 14th to 38th week of gestation. The 6th and 7th scan showed that 4 women had placentas of the same size. The mean placental volume increases linearly from the 14th till the 38th week of gestation, with a constant mean growth rate of 29.97 ml/week. The median placental volume extrapolated to delivery was to 856 ml (range 602-1,050 ml). The median weight of the exsanguinated placenta after delivery was 640 g (range 500-787 g). All pregnancies were carried to term, resulting in the delivery of healthy infants with good correlation between placental size and birth weight (R = 0.56, p = 0.009). Conclusion: Placental growth was measured systematically in a longitudinal study through the second and third trimesters using MRI. MRI provides a safe and feasible method to measure placental growth. The mean placental growth was linear throughout the second and third trimesters. (C) 2016 S. Karger AG, Basel