Differential role of afferent and efferent renal nerves in the maintenance of early- and late-phase Dahl S hypertension
Differential role of afferent and efferent renal nerves in the maintenance of early- and late-phase Dahl S hypertension
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DOI：
10.1152/ajpregu.00408.2015
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发表时间：
2016-02-01
影响因子：
2.8
通讯作者：
Osborn, John W.
中科院分区：
文献类型：
--
作者：
Foss, Jason D.;Fink, Gregory D.;Osborn, John W.
临床数据表明，肾去神经支配（RDNX）可能是一种有效的治疗人类高血压的方法;然而，目前还不清楚这种治疗效果是由于传入或传出肾神经的消融。我们以前已经证明，RDNX降低高血压达尔盐敏感（S）大鼠的动脉压，与临床试验中观察到的程度相似。此外，我们最近开发了一种选择性消融肾传入神经（renal-CAP）的方法。在本研究中，我们测试的假设，即RDNX在达尔S大鼠的抗高血压作用是由于消融传入肾神经通过比较的效果完全RDNX肾CAP在两个阶段的高血压达尔S大鼠。在早期阶段，大鼠在平均动脉压（MAP）接近140 mmHg时，在高NaCl喂养3周后接受治疗。在晚期，大鼠在高NaCl喂养9周后接受治疗，此时MAP接近170 mmHg。与假手术相比，RDNX在早期和晚期均使MAP降低10 mmHg，而renal-CAP无降压作用。这些结果表明，在Dahl S大鼠中，RDNX的抗高血压作用不依赖于预处理动脉压，也不是由于传入肾神经的消融。
Clinical data suggest that renal denervation (RDNX) may be an effective treatment for human hypertension; however, it is unclear whether this therapeutic effect is due to ablation of afferent or efferent renal nerves. We have previously shown that RDNX lowers arterial pressure in hypertensive Dahl salt-sensitive (S) rats to a similar degree observed in clinical trials. In addition, we have recently developed a method for selective ablation of afferent renal nerves (renal-CAP). In the present study, we tested the hypothesis that the antihypertensive effect of RDNX in the Dahl S rat is due to ablation of afferent renal nerves by comparing the effect of complete RDNX to renal-CAP during two phases of hypertension in the Dahl S rat. In the early phase, rats underwent treatment after 3 wk of high-NaCl feeding when mean arterial pressure (MAP) was similar to 140 mmHg. In the late phase, rats underwent treatment after 9 wk of high NaCl feeding, when MAP was similar to 170 mmHg. RDNX reduced MAP similar to 10 mmHg compared with sham surgery in both the early and late phase, whereas renal-CAP had no antihypertensive effect. These results suggest that, in the Dahl S rat, the antihypertensive effect of RDNX is not dependent on pretreatment arterial pressure, nor is it due to ablation of afferent renal nerves.