Preparation of clarithromycin.: Selective 6-O-methylation of the novel erythromycin A 9-O-(2-pyrimidyl)oxime
Preparation of clarithromycin.: Selective 6-O-methylation of the novel erythromycin A 9-O-(2-pyrimidyl)oxime
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DOI：
10.1016/j.tetlet.2006.12.124
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发表时间：
2007-02-19
影响因子：
1.8
通讯作者：
Asensio, Ramon
中科院分区：
文献类型：
--
作者：
Brunet, Ernesto;Munoz, Dulce Maria;Asensio, Ramon
本文报道了一种新的克拉霉素衍生物9-嘧啶肟红霉素A在C（6）-OH上的高区域选择性O-甲基化反应。本文还报道了6，11-O-二甲基和6，11，12-O-三甲基红霉素A的简便合成。这些化合物可用作质量控制过程中评估克拉霉素纯度的标准品。(c)2007爱思唯尔有限公司保留所有权利。
A new method for the preparation of clarithromycin is described through the highly regioselective O-methylation at C(6)-OH of the novel derivative 9-pyrimidyloxime erythromycin A. The facile synthesis of 6,11-O-dimethyl- and 6,11,12-O-trimethyl erythromycin A is also reported. These compounds are useful as standards to assess clarithromycin purity in quality control processes. (c) 2007 Elsevier Ltd. All rights reserved.