Tumor necrosis factor locus polymorphisms in rheumatoid arthritis.
Tumor necrosis factor locus polymorphisms in rheumatoid arthritis.
复制标题
类风湿关节炎中肿瘤坏死因子位点多态性。
DOI：
10.1111/j.1399-0039.1997.tb02874.x
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
C. Campbell
中科院分区：
文献类型：
--
作者：
M. Field;G. Gallagher;J. Eskdale;F. Mcgarry;S. Richards;R. Munro;H. Oh;C. Campbell
我们检测了肿瘤坏死因子（TNF）位点的6个多态性元素，并确定了它们在98名高加索类风湿性关节炎患者中的等位基因分布，并与91名种族匹配的对照组进行了比较。不论DR4是否存在，4个双等位基因位点的多态元素在患者和对照组之间的分布相似。两组之间在TNFa和TNFe位点上观察到差异，但这些差异与已知存在于类风湿关节炎患者中的扩展MHC单倍型一致。因此，本研究表明，TNF位点对类风湿关节炎易感性的遗传背景的独立贡献很小，如果有的话。
We examined six polymorphic elements in the tumor necrosis factor (TNF) locus and determined their allelic distribution in 98 Caucasian rheumatoid arthritis patients in comparison with 91 ethnically-matched controls. Polymorphic elements at four biallelic sites were distributed similarly between patients and controls, irrespective of the presence or absence of DR4. Differences were observed between the two groups at the TNFa and TNFe loci, but these were consistent with extended MHC haplotypes known to be present in rheumatoid arthritis patients. Therefore, this study suggests that there is little, if any, independent contribution of the TNF locus to the genetic background for rheumatoid arthritis susceptibility.
影响因子：
7.7
作者：
Goodarzi, MO;Taylor, KD;Rotter, JI
通讯作者：
Rotter, JI