Wada testing reveals frontal lateralization for the memorization of words and faces.
Wada testing reveals frontal lateralization for the memorization of words and faces.
复制标题
世界反兴奋剂机构的测试揭示了记忆单词和面孔的额侧化。
DOI：
10.1162/089892902317205375
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Petersen,SE
中科院分区：
文献类型：
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作者：
Kelley,WM;Ojemann,JG;Wetzel,RD;Derdeyn,CP;Moran,CJ;Cross,DT;Dowling,JL;Miller,JW;Petersen,SE
神经影像学研究表明，额叶和内侧颞叶皮层的特定区域在记忆形成过程中参与其中。此外，这些区域之间存在专门化，使得语言材料似乎优先参与左侧区域，而非语言材料主要参与右侧区域。然而，一个悬而未决的问题是，额叶区域在多大程度上有助于成功的记忆形成。本研究调查这个问题，使用可逆的损伤技术称为和田测试。患者在记忆单词和陌生面孔的同时，他们的左右半球部分被安地妥钠暂时麻醉。随后的记忆测试显示，左半球麻醉后，面孔比单词记忆得更好，而右半球麻醉后，单词比面孔记忆得更好。重要的是，对受杏仁核影响的循环的检查进一步表明，这些记忆障碍不是由内侧颞区的直接麻醉引起的。这些结果表明，在正常表现的情况下，额叶区域也可能有助于记忆的形成。
Neuroimaging studies have suggested that specific regions of the frontal and medial temporal cortex are engaged during memory formation. Further, there is specialization across these regions such that verbal materials appear to preferentially engage the left regions while nonverbal materials primarily engage the right regions. An open question, however, has been to what extent frontal regions contribute to successful memory formation. The present study investigates this question using a reversible lesion technique known as the Wada test. Patients memorized words and unfamiliar faces while portions of their left and right hemispheres were temporarily anesthetized with sodium amytal. Subsequent memory tests revealed that faces were remembered better than words following left-hemisphere anesthesia, whereas words were remembered better than faces following right-hemisphere anesthesia. Importantly, inspection of the circulation affected by the amytal further suggests that these memory impairments did not result from direct anesthetization of the medial temporal regions. Taken in the context of the imaging findings, these results suggest that frontal regions may also contribute to memory formation in normal performance.