Influence of glaucomatous visual field loss on health-related quality of life
Influence of glaucomatous visual field loss on health-related quality of life
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DOI：
10.1001/archopht.1997.01100150779014
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发表时间：
1997-06-01
影响因子：
--
通讯作者：
Mangione, CM
中科院分区：
文献类型：
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作者：
Gutierrez, P;Wilson, MR;Mangione, CM
我们研究了青光眼视野缺陷对视力目标和一般健康相关生活质量的影响。在定期的眼科护理访问期间，评估了5个青光眼治疗类别和5个三级眼科实践的正常参照组的视力目标和一般健康状况。样本包括147名特定青光眼治疗类别的患者和44名参照组患者。对于青光眼患者，资格包括至少在登记前一年被诊断为青光眼，并且没有其他眼病的证据。参与者完成了两项以视力为目标的调查，即国家眼科研究所视觉功能问卷和VF-14，以及与健康相关的一般生活质量测量，即医疗结果研究36项简表。来自自动视野检查(Humphrey field Analyzer 24-2，Humphrey Instruments，San Leandro，加利福尼亚州)的数据被用来为所有参与者生成高级青光眼干预研究分数。随机抽取一半样本，来自青光眼患者和参照组参与者的《医学结果研究》36项简表得分相似。然而，以视力为目标的调查的比较显示，11个国家眼科研究所视觉功能问卷量表中有7个的平均差异显著，而VF-14有显著差异的趋势(线性回归P<；0.07)。视力越好，视野缺陷越大，国家眼科学会视觉功能问卷得分越差(P<；0.05)，以及VF-14得分越差。这些发现对于视力较好的患者视野损失最严重的患者最为显著。视力目标问卷对青光眼和正常参照者之间的差异比一般的健康相关生活质量测量更敏感，我们的研究结果表明，视力目标健康相关生活质量自我报告对视野丧失敏感，与临床检查结合使用可能有助于全面了解青光眼治疗的结果。
We examined the influence of glaucomatous visual field defects on vision-targeted and generic health-related quality of life. Vision-targeted and generic health status were assessed across 5 glaucoma treatment categories and a normal reference group from 5 tertiary care ophthalmology practices during regularly scheduled eye care visits. The sample consisted of 147 patients who were members of specific glaucoma treatment categories and 44 reference group patients. For patients with glaucoma, eligibility included a diagnosis of glaucoma at least 1 year prior to enrollment and no evidence of other eye disease. Participants completed 2 vision-targeted surveys, the National Eye Institute Visual Functioning Questionnaire and the VF-14, and a generic health-related quality of life measure, the Medical Outcomes Study 36-Item Short Form. Data from automated perimetry (Humphrey Field Analyzer 24-2, Humphrey Instruments, San Leandro, Calif) were used to generate Advanced Glaucoma Intervention Study scores for all participants. The Medical Outcomes Study 36-Item Short Form scores from glaucoma and reference group participants collected on a random half of the sample were similar. However, comparisons of the vision-targeted surveys demonstrated significant mean differences on 7 of 11 National Eye Institute Visual Functioning Questionnaire scales, and a trend toward significant differences for the VF-14 (P < .07 by linear regression). Greater visual field defects in the better eye were significantly associated with poorer National Eye Institute Visual Functioning Questionnaire scores (P < .05), as well as with worse VF-14 scores. These findings were most dramatic for patients with the most severe field loss in the better eye. Vision-targeted questionnaires were more sensitive than a generic health-related quality of life measure to differences between glaucoma and normal reference participants, Our findings indicate that self-reports of vision-targeted health-related quality of life are sensitive to visual field loss and may be useful in tandem with the clinical examination to fully understand outcomes of treatment for glaucoma.