Contribution of environmental factors to the risk of male infertility
Contribution of environmental factors to the risk of male infertility
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DOI：
10.1093/humrep/16.8.1768
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发表时间：
2001-08-01
影响因子：
6.1
通讯作者：
Multigner, L
中科院分区：
文献类型：
--
作者：
Oliva, A;Spira, A;Multigner, L
背景：越来越多的报告表明，由人类活动引入和传播的环境中的化学和物理因素可能影响人类的男性生育能力。我们调查了暴露于环境因素与精液特征之间的关系，以及寻求不育治疗的男性血清中生殖激素的浓度。方法：我们研究了连续招募的225对男性伴侣，他们在1995年至1998年期间在阿根廷滨海Sur地区（世界上最具生产力的农业区之一）进行了第一次不孕咨询。结果：多变量logistic回归模型显示，暴露于农药和溶剂与精子阈值显著相关，远低于男性生育能力的限制。我们还发现，接触杀虫剂的男性血清雌二醇浓度较高，而接触溶剂的男性血清黄体生成素浓度低于未接触杀虫剂的男性。所有这些影响在原发性不育症男性中比继发性不育症男性中更大。结论：我们已经表明，环境因素有助于不孕症的严重程度，这可能会加重已有的遗传或医学风险因素的影响。
BACKGROUND: An increasing number of reports suggest that chemical and physical agents in the environment, introduced and spread by human activity, may affect male fertility in humans. We investigated the relationships between exposure to environmental agents and seminal characteristics, and the concentrations of reproductive hormones in the serum of men seeking infertility treatment. METHODS: We studied 225 male partners from consecutively recruited couples, who had their first infertility consultation between 1995 and 1998, in the Litoral Sur region of Argentina, one of the most productive farming regions in the world. RESULTS: A multivariate logistic regression model showed that exposure to pesticides and solvents is significantly associated with sperm threshold values well below the limit for male fertility. We also found that men exposed to pesticides had higher serum oestradiol concentrations, and that men exposed to solvents had lower LH concentrations than non-exposed men. All of these effects were greater in men with primary infertility than in men with secondary infertility. CONCLUSION: We have shown that environmental factors contribute to the severity of infertility, and that this may worsen the effects of pre-existing genetic or medical risk factors.