Effects of C-peptide on renal function at the early stage of experimental diabetes.
Effects of C-peptide on renal function at the early stage of experimental diabetes.
复制标题
C肽对实验性糖尿病早期肾功能的影响。
DOI：
10.1046/j.1523-1755.1998.00074.x
复制
发表时间：
1998
影响因子：
19.6
通讯作者：
Bo
中科院分区：
文献类型：
--
作者：
Mats Sjöquist;Wan Huang;Bo
背景
BACKGROUND
C-peptide has been reported to have biological effects on renal function early in the course of diabetes. This investigation was initiated to elucidate and amplify these findings with respect to protein leakage, hyperfiltration and renal functional reserve in diabetic rats.
METHODS
Acute effects of 140 minutes i.v. infusion of human C-peptide (0.5 nmol x min(-1) x kg(-1) body wt) on renal function and urinary protein leakage were studied in anesthetized diabetic male rats two weeks after streptozotocin injection without insulin treatment. Streptozotocin-induced diabetic rats were studied with (N = 6) and without C-peptide (N = 11) treatment. The two groups showed a similarly elevated blood glucose concentration during the study. Age-matched normal rats served as controls (N = 5). Glomerular filtration rate (GFR) was measured by inulin clearance in the basal state and during a 60-minute glycine infusion (0.22 mmol x min(-1) x kg(-1) body wt)-resembling a protein load challenge-to test the renal functional reserve in all three groups.
RESULTS
In the basal state, the non-C-peptide-treated diabetic rats displayed increased GFR and increased total protein leakage compared with normal rats. Whereas normal rats responded to glycine infusion with an increase in GFR, no increase occurred in diabetic rats not treated with C-peptide. In diabetic rats given C-peptide, this reduced the initial glomerular hyperfiltration prior to glycine infusion. This indicates a specific effect, since a control peptide with the same amino acid composition as C-peptide, but in a randomized sequence, had no such effect. C-peptide also restored half of the normal renal functional reserve and resulted in 70% lower (P < 0.05) total protein leakage compared with that in rats not given C-peptide.
CONCLUSION
Thus, short-term infusion of C-peptide had beneficial effects on protein leakage and hyperfiltration and improved the renal functional reserve in rats with experimental diabetes.
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卡托普利可增强成人糖尿病患者对氨基酸输注的肾脏反应。
DOI：
10.1152/ajprenal.1988.255.4.f755
发表时间：
1988
期刊：
The American journal of physiology
影响因子：
--
作者：
Slomowitz,LA;Hirschberg,R;Kopple,JD
通讯作者：
Kopple,JD
影响因子：
56.9
作者：
Ido, Y;Vindigni, A;Williamson, JR
通讯作者：
Williamson, JR
减少肾小球前负荷和后负荷作为降低尿蛋白渗漏的工具：此类治疗是否也有助于改善肾功能结果？
DOI：
10.1681/asn.v371333
发表时间：
1993
期刊：
Journal of the American Society of Nephrology : JASN
影响因子：
--
作者：
deJong,PE;Anderson,S;deZeeuw,D
通讯作者：
deZeeuw,D
影响因子：
19.6
作者：
TUCKER, BJ;ANDERSON, CM;BLANTZ, RC
通讯作者：
BLANTZ, RC