ABSORPTION OF UNALTERED FOLIC ACID FROM GASTRO-INTESTINAL TRACT IN MAN
ABSORPTION OF UNALTERED FOLIC ACID FROM GASTRO-INTESTINAL TRACT IN MAN
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DOI：
10.1111/j.1365-2141.1967.tb08833.x
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发表时间：
1967-01-01
影响因子：
6.5
通讯作者：
COOPER, BA
中科院分区：
文献类型：
--
作者：
WHITEHEAD, VM;COOPER, BA
在人脐静脉插管过程中，测定了口服叶酸后的肝门脉和全身血浆叶酸水平。右心插管时取肝静脉血。用干酪乳杆菌、粪链球菌和TEAE[三乙氨基乙基]-纤维素层析法进行的一系列叶酸测定表明，叶酸可以迅速吸收到门静脉血中，而不需要进行代谢转换。全身和肝静脉血中叶酸水平上升的延迟，以及随后离开肝脏的血液中大量叶酸和甲基叶酸的发现，表明该器官是叶酸代谢的主要部位。
Hepatic portal and systemic plasma folate levels were determined in human subjects during umbilical-vein catheterization after oral administration of folic acid. Hepatic-vein blood was obtained during right heart catheterization. Serial folate measurements with Lactobacillus casei and Streptococcus fecalis and TEAE [triethylaminoethyl]-cellulose chromatography revealed that folic acid is rapidly absorbed into the portal blood without undergoing metabolic conversion. A delay in rise in folate levels in systemic and hepatic-vein blood, together with the finding of large amounts of folic acid and methylfolatein blood subsequently leaving the liver, indicates that this organ is the major site of folic-acid metabolism.