Cardiovascular risk factors for retinal vein occlusion and arteriolar emboli - The Atherosclerosis Risk in Communities & Cardiovascular Health Studies
Cardiovascular risk factors for retinal vein occlusion and arteriolar emboli - The Atherosclerosis Risk in Communities & Cardiovascular Health Studies
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DOI：
10.1016/j.ophtha.2004.10.039
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发表时间：
2005-04-01
期刊：
影响因子：
13.7
通讯作者：
Sharrett, AR
中科院分区：
文献类型：
--
作者：
Wong, TY;Larsen, EKM;Sharrett, AR
目的：研究视网膜静脉阻塞和小动脉栓塞与心血管疾病的关系。设计：基于人群的横断面研究。参与者：来自社区动脉粥样硬化风险研究（n = 12642;平均年龄60岁）和心血管健康研究方法：使用标准化的方案，从一张非散瞳视网膜照片中识别视网膜静脉阻塞和小动脉栓塞。还对动静脉切口和局灶性小动脉狭窄的照片进行了分级。所有参与者进行了全面的系统评价，包括标准化的颈动脉Ultrasonography.Main Outcome Measures：Retinal vein occlusion and arteriolar embolis.Results：视网膜静脉阻塞和小动脉栓塞的患病率分别为0.3%（n = 39例）和0.2%（n = 34例），分别。调整年龄后，视网膜静脉阻塞与高血压相关（比值比[OR]，2.96; 95%置信区间[CI]，1.43-6.14），收缩压（BP）（OR，4.12; 95% CI，1.40-12.16;最高四分位数与最低四分位数），舒张压（OR，2.64; 95% CI，1.07-6.46;最高四分位数与最低四分位数），颈动脉斑块（OR，5.62; 95%CI，2.60-12.16），体重指数（OR，3.88; 95% CI，1.23-12.18;最高四分位数与最低四分位数），血浆纤维蛋白原（OR，3.29; 95% CI，1.08-10.02;最高四分位数与最低四分位数）、动静脉切口（OR，4.09; 95% CI，2.00-8.36）和局灶性小动脉狭窄（OR，5.17; 95% CI，2.59-10.29）。调整年龄后，视网膜小动脉栓塞与高血压相关（OR，3.14; 95% CI，1.44-6.84），收缩压（OR，3.46; 95% CI，1.13-10.65;最高四分位数与最低四分位数），冠心病患病率（OR，2.33; 95%CI，1.01-5.42），颈动脉斑块（OR，4.62; 95% CI，1.85-11.57），血浆脂蛋白（a）（OR，3.69; 95% CI，1.20-11.41;最高四分位数与最低四分位数），血浆纤维蛋白原（OR，3.09; 95% CI，0.98-9.76;最高四分位数与最低四分位数）和当前吸烟（OR，3.08; 95% CI，1.47-6.47）。大约四分之一的视网膜静脉阻塞和小动脉栓塞的参与者有颈动脉斑块的证据，定义从ultrasound.Conclusions：视网膜静脉阻塞和视网膜小动脉栓塞与颈动脉疾病，高血压，和其他心血管危险因素。(c)2005年，美国眼科学会。
Objective: To examine the associations of retinal vein occlusion and arteriolar emboli with cardiovascular disease.Design: Population-based cross-sectional study.Participants: Pooled from the Atherosclerosis Risk in Communities Study (n = 12 642; mean age, 60 years) and the Cardiovascular Health Study (n = 2824; mean age, 79 years).Methods: Retinal vein occlusion and arteriolar emboli were identified from a single nonmydriatic retinal photograph using a standardized protocol. Photographs were also graded for arteriovenous nicking and focal arteriolar narrowing. All participants had a comprehensive systemic evaluation, including standardized carotid ultrasonography.Main Outcome Measures: Retinal vein occlusion and arteriolar emboli.Results: Prevalences of retinal vein occlusion and arteriolar emboli were 0.3% (n = 39 cases) and 0.2% (n 34 cases), respectively. After adjusting for age, retinal vein occlusion was associated with hypertension (odds ratio [OR], 2.96; 95% confidence interval [CI], 1.43-6.14), systolic blood pressure (BP) (OR, 4.12; 95% CI, 1.40-12.16; highest quartile vs. lowest), diastolic BP (OR, 2.64; 95% CI, 1.07-6.46; highest quartile vs. lowest), carotid artery plaque (OR, 5.62; 95% CI, 2.60-12.16), body mass index (OR, 3.88; 95% CI, 1.23-12.18; highest quartile vs. lowest), plasma fibrinogen (OR, 3.29; 95% CI, 1.08-10.02; highest quartile vs. lowest), arteriovenous nicking (OR, 4.09; 95% CI, 2.00-8.36), and focal arteriolar narrowing (OR, 5.17; 95% CI, 2.59-10.29). After adjusting for age, retinal arteriolar emboli were associated with hypertension (OR, 3.14; 95% CI, 1.44-6.84), systolic BP (OR, 3.46; 95% CI, 1.13-10.65; highest quartile vs. lowest), prevalent coronary heart disease (OR, 2.33; 95% CI, 1.01-5.42), carotid artery plaque (OR, 4.62; 95% CI, 1.85-11.57), plasma lipoprotein (a) (OR, 3.69; 95% CI, 1.20-11.41; highest quartile vs. lowest), plasma fibrinogen (OR, 3.09; 95% CI, 0.98-9.76; highest quartile vs. lowest), and current cigarette smoking (OR, 3.08; 95% CI, 1.47-6.47). Approximately a quarter of participants with retinal vein occlusion and arteriolar emboli had evidence of carotid artery plaque as defined from ultrasound.Conclusions: Retinal vein occlusion and retinal arteriolar emboli are associated with carotid artery disease, hypertension, and other cardiovascular risk factors. (c) 2005 by the American Academy of Ophthalmology.