Bench-to-bedside and bedside back to the bench; coordinating clinical and experimental traumatic brain injury studies.
Bench-to-bedside and bedside back to the bench; coordinating clinical and experimental traumatic brain injury studies.
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DOI：
10.3389/fneur.2012.00003
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发表时间：
2012
影响因子：
3.4
通讯作者：
Bellander BM
中科院分区：
文献类型：
--
作者：
Agoston DV;Risling M;Bellander BM
创伤性脑损伤(TBI)在几乎每个国家都是导致死亡和长期残疾的主要原因之一。神经重症监护的进展导致发病率稳步下降，但严重长期残疾的人数并未发生显著变化，而中度残疾的人数在过去30年中稳步上升。尽管进行了多年密集的临床前研究--花费了数百万美元--但几乎没有专门开发的药物来减轻脑损伤的后果。在这里，我们讨论了临床和实验脑损伤研究之间存在的一些差距，这些差距可能是导致目前状况的原因之一。我们这样做是希望临床、基础和翻译科学家将设计和协调研究，以便为脑外伤患者实现最大益处。综上所述，我们建议：(1)为实验性脑损伤研究制定基于共识的指南，类似于临床上的“最佳实践”；(2)为临床数据收集和存储以及实验脑损伤数据收集和沉积创建基于共识的模板；(3)使用系统生物学方法并创建一个数据库，用于整合来自基础和临床研究的现有数据。
Traumatic brain injury (TBI) is one of the leading cause of death and long-term disability in virtually every country. Advances in neurointensive care have resulted in steadily decreasing morbidity, but the number of individuals with severe long-term disability have not changed significantly and the number of moderate disability has shown steady increase over the last 3 decades. Despite years of intensive preclinical research – and millions spent – there are virtually no drugs specifically developed to mitigate the consequences of TBI. Here we discuss some of the existing gaps between clinical and experimental TBI studies that may have contributed to the current status. We do this hoping that clinical, basic, and translational scientists will design and coordinate studies in order to achieve maximum benefits for TBI patients. In conclusion, we suggest to: (1) Develop consensus-based guidelines for experimental TBI research, similar to “best practices” in the clinic; (2) Generate a consensus-based template for clinical data collection and deposition as well as for experimental TBI data collection and deposition; (3) Use a systems biology approach and create a database for integrating existing data from basic and clinical research.